Araştırma Çıktıları
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Item Cranial MRI Abnormalities and Long-term Follow-up of the Lesions in 770 Girls With Central Precocious Puberty(ENDOCRINE SOC, 2021-01-01) Helvacioglu, Didem; Turan, Serap Demircioglu; Guran, Tulay; Atay, Zeynep; Dagcinar, Adnan; Bezen, Digdem; Ozturan, Esin Karakilic; Darendeliler, Feyza; Yuksel, Aysegul; Dursun, Fatma; Kilinc, Suna; Semiz, Serap; Abali, Saygin; Yildiz, Metin; Onder, Asan; Bereket, AbdullahContext: Central precocious puberty (CPP) may arise from central nervous system (CNS) lesions in a few affected girls. Recently, the incidence of girls with CPP has increased mostly in 6-8 year olds, in whom the necessity of magnetic resonance imaging (MRI) is debated. Objective: To investigate the frequency, long-term outcome and potential predictors of CNS lesions in a large cohort of girls with CPP. Methods: A multicenter cohort of 770 Turkish girls with CPP who had systematic cranial MRI between 2005 and 2017. Age at puberty onset was <6 years in 116 and 6-8 years in 654. CNS lesions were followed until final decision(6.2 +/- 3.1 years). Potential predictors of CNS lesions were evaluated by univariate analyses. Results: A total of 104/770 (13.5\%) girls had abnormal brain MRI. Of these, 2.8\% were previously known CNS lesions, 3.8\% had newly detected and causally related CNS lesions, 3.1 \% were possibly, related and 3.8\% were incidental. Only 2 (0.25\%) neoplastic lesions (1 low grade glioma and 1 meningioma) were identifiedItem Influence of Infraspinatus and Subscapularis Pathologies on Supraspinatus Muscle Atrophy - A Retrospective Cohort Study(MALAYSIAN ORTHOPAEDIC ASSOC, 2020-01-01) Altan, E.; Nayman, A.; Yildirim, A.; Ozbaydar, M. U.; Ciftci, S.; Karahan, M.Introduction: Many factors could affect the supraspinatus (SSP) muscle after tendon rupture. We aimed to determine how infraspinatus and subscapularis tendon problems affect supraspinatus muscle atrophy associated with tears, in a retrospective cohort study conducted in a tertiary-level centre. Materials and Methods: Fifty-eight patients with a full-thickness SSP tendon tear who fulfilled the inclusion criteria were enrolled in the study. They were evaluated for tear retraction, fatty degeneration, and other rotator cuff tendon pathologies. Supraspinatus muscle was assessed using the Goutallier classification, and its average area was also measured. Accompanying lesions of the subscapularis and infraspinatus tendons and degree of supraspinatus muscle atrophy were evaluated using magnetic resonance imaging. Results: Our results showed that supraspinatus tendon tears ranged between 3mm and 41mm, and the estimated average cross-sectional area of the SSP muscle was 247.6mm(2). Any degree of infraspinatus tendon pathology, ranging from tendinosis to full-thickness tears, was significantly correlated with the SSP muscle area (P < 0.05). The subscapularis tendon pathologies did not show a similar correlation. The interobserver and intraobserver reliabilities of the measurements were graded as excellent. Conclusion: Impairment of any of the rotator cuff muscles may affect the other muscles inversely. Our study showed that all infraspinatus tendon pathologies and partial subscapularis tears affect and alter the SSP muscle belly. We suggest early intervention for supraspinatus tears to avoid further fatty degeneration, as muscle atrophy and fatty degeneration progress in combination with the accompanying lesions.Item Diffusion tensor imaging in early amyotrophic lateral sclerosis using 3T magnetic resonance imaging(EGE UNIV, 2018-01-01) Sarsilmaz, Aysegul; Firat, Zeynep; Ulug, Aziz M.; Karlikaya, Geysu; Bingol, Canan Aykut; Hamamci, Andac; Kovanlikaya, IlhamiObjective: Amyotrophic lateral sclerosis (ALS) is a multisystem condition which impairs white matter, corticospinal tract and frontotemporal functions including cognition and behavior. This study aimed to perform diffusion tensor imaging (DTI) to detect white matter microstructural abnormalities, and also understanding the pathophysiology in ALS using 3T magnetic resonance imaging. Methods: The study examined 12 patients (7 males, 5 females) with sporadic ALS and 10 subjects in the control group (7 males, 3 females) by voxel-based analysis of DTI with 3T MRI. We compared fractional anisotropy (FA) and apparent diffusion coefficient (ADC) parameters in the corticospinal tracts among patients who had ALS and those in the healthy control by DTI region of interest (ROI) and tractography techniques. Results: The FA and ADC measurements of the patient group were respectively 0.638 +/- 0.041 and 0.350 +/- 0.01 (p<0.001). The results of the healthy control group were respectively 0.701 +/- 0.054 and 0.288 +/- 0.027 (p<0.05). DTI showed decreased fractional anisotropy in bilateral corticospinal tracts and internal capsule posterior crus. There was a correlation between the FA reductions in this region and the severity of the disease in the patients with ALS. Conclusion: Consequently, with this longitudinal DTI study, the progress of upper motor fiber degeneration in ALS was demonstrated. It may be useful to utilize DTI to monitor the progress and effectiveness of treatment interventions, as well as understanding the pathophysiology of ALS.Item A Comparative Study of Multiparametric MRI Sequences in Measuring Prostate Cancer Index Lesion Volume(UBIQUITY PRESS LTD, 2022-01-01) Bagcilar, Omer; Alis, Deniz; Seker, Mustafa; Erdemli, Servet; Karaarslan, Umut; Kus, Aylin; Kayhan, Cavit; Saglican, Yesim; Kural, Ali; Karaarslan, ErcanObjectives: To compare the effectiveness of individual multiparametric prostate MRI (mpMRI) sequences-T2W, diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC), and dynamic contrast-enhanced (DCE)-in assessing prostate cancer (PCa) index lesion volume using whole-mount pathology as the ground-truth