Araştırma Çıktıları

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    The Outcome of Patients with Triple Negative Breast Cancer: The Turkish Oncology Group Experience
    (AVES, 2014-01-01) Eralp, Yesim; Kilic, Leyla; Alco, Gul; Basaran, Gul; Dogan, Mutlu; Dincol, Dilek; Demirci, Senem; Icli, Fikri; Onur, Handan; Saip, Pinar; Haydaroglu, Ayfer
    Objective:Triple negative breast cancer (TNBC) is generally considered as a poorer prognostic subgroup, with propensity for earlier relapse and visceral involvement. The aim of this study is to evaluate the outcome of non-metastatic TNBC patients from different centers in Turkey and identify clinical and pathologic variables that may effect survival. Materials and Methods:Between 1993-2007, from five different centers in Turkey, 316 nonmetastatic triple negative breast cancer patients were identified with follow-up of at least 12 months. The data was collected retrospectively from patient charts. The prognostic impact of several clinical variables were evaluated by the Kaplan-Meier and Cox multivariate anayses. Results:Mean age at diagnosis was 49 years (range:24-82). The majority of the patient group had invasive ductal carcinoma (n:260, 82.3\%) and stage II disease (n:164
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    The Impact and Prognostic Significance of Chronic Lymphocytic Leukemia Upregulated 1 (CLLU1) Gene Expression in Patients with Chronic Lymphocytic Leukemia: A Single Center Experience
    (OXFORD UNIV PRESS, 2020-01-01) Sevinc, Mustafa; Karabulut, Aydin; Eskazan, Ahmet Emre; Tatonyan, Suzin Catal; Ozbek, Ugur; Soysal, Teoman
    Objectives: To determine CLLU1 gene levels and the relationship of that gene among other prognostic parameters in patients with chronic lymphocytic leukemia. Methods: Bone-marrow infiltration pattern, beta 2-microglobulin (beta(2)-M), cluster of differentiation (CD)38, and ZAP-70 status were recorded. CLLU1 levels were assessed by real-time polymerase chain reaction (RT-PCR) and expressed as folds. The relationship between CLLU1 and other known prognostic parameters was evaluated. Results: CLLU1 expression was positive in 81 patients and negative in 3 patients. The median (interquartile range {[}IQR]) CLLU1 level was 6.45 folds (3.75-16.57 folds) in patients with beta(2)-M normal values and 16.22 folds (3.91-62.00 folds) in patients with increased beta(2)-M (P = .15). Patients with a higher CD38 value than the median level had 3 times higher CLLU1 levels than the other group (P = .07). The median (IQR) CLLU1 level was 4.25 folds (2.75-13.71 folds) in patients with CLL who tested negative on ZAP-70, whereas it was 49.52 folds (15.06-446.36 folds) in those who tested positive via ZAP-70 (P = .005). Conclusions: CLLU1 is a specific parameter to CLL, and its level corresponds well with the ZAP-70 level.
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    Predictive Values of Systemic Inflammation Index in Prognosis of Patients with Laryngeal Cancer
    (KARE PUBL, 2020-01-01) Demir, Atakan; Alan, Ozkan; Surmeli, Mehmet
    Objectives: Laryngeal cancer is the most common cancer in head and neck cancer group, of which it constitutes 75\%. Squamous cell carcinoma (SCC) is the most common histological subtype. Systemic or local inflammation is a well known promotor for cancer development and progression. Systemic immune inflammation index (S II) has been reported as an independent prognostic parameter in various cancers. We aimed to evaluate the capability of SII in predicting the risk of recurrence in patients with operable laryngeal cancer. Methods: We retrospectively collected the data of 100 laryngeal SCC patients who underwent surgery between 2016 and 2018. Neutrophil, lymphocyte, and platelet (Plt) counts were recorded. The SII was calculated as follows: SII= Neutrophile counts {*}platelet counts/lymphocyte counts. Results: SI index was found to be an independent prognostic factor as affecting disease recurrence (p<0.05). We found that patients with SII >891 had a risk of disease recurrence of approximately three times more than patients with SII = <891.78 (HR: 3.06 (95\% CI: 3.42-132.64). Conclusion: This was the first study to demonstrate that preoperative SI index is a simple and powerful independent predictive index that predicts the risk of disease recurrence in patients with laryngeal cancer.
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    Prognostic value of aVR lead and the well-known risk factors in acute ST-segment elevated myocardial infarction
    (MEDCOM LTD, 2011-01-01) Eren, S. H.; Aktas, C.; Korkmaz, I.; Karcioglu, O.; Coskun, A.; Guven, F. M. Kukul
    Objective: The present study was designed to analyse the effect of ST segment changes in aVR lead and the well-known risk factors in ST-segment elevated myocardial infarction (STEMI) patients. Materials and Methods: A total of 250 patients who were admitted between 2009 and 2010 with STEMI and mm ST-segment elevation in aVR lead were enrolled in the study. The patients were followed for life-threatening events like acute pulmonary oedema, atrial fibrillation, AV block, ventricular tachycardia, length of stay in hospital and death. Results: Among the enrolled patients, 222 were discharged and 28 died. Pulmonary oedema and mortality rates were significantly higher in patients with ST-segment elevation in aVR lead (both p=0.001). Conclusions: There is a correlation of ST-segment elevation in aVR lead with poor outcome in STEMI. Therefore aVR lead must be analysed as well as the other leads and well-known risk factors while it estimates the prognosis. (Hong Kong j.emerg.med. 2011
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    Relationships Between Clinical Behavior of Laryngeal Squamous Cell Carcinomas and Expression of VEGF, MMP-9 and E-Cadherin
    (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2013-01-01) Akdeniz, Onder; Akduman, Davut; Haksever, Mehmet; Ozkarakas, Haluk; Muezzinoglu, Bahar
    The biological mechanisms of cancer and associations with behavior of tumours need to be studied to understand progression and determine appropriate treatments. Here we investigated expression of VEGF, MMP-9 and E-cadherin in laryngeal SCCs and their relations with clinical behavior. This prospective study was based on 38 surgical specimens from patients with primary laryngeal SCC and data recorded in their cards. Expression of the three factors in tumor tissue was examined using immunohistochemistry and correlations with clinical parameters of primary tumors, regional lymph node metastases, stage of disease, histopathologic differentiation, and vascular/cartilage invasion were investigated. Regarding the cases with positive MMP-9 expression, the difference between well and moderately/poorly differentiated tumors was statistically significant. However, differences between early stage (stage I and II) and late-stage (stage III and IV) tumours, and between positive and negative for pLN metastasis were not. No significant relationship between positive VEGF and tumor differentiation or stage was apparent, but E-cadherin levels significantly differed between well and moderately/ poorly differentiated tumours and with the presence of pLN metastasis. E-cadherin staining did not vary between MMP-9 positive and negative cases. In conclusion, MMP-9 may be a negative predictor of differentiation in laryngeal SCC, while E-cadherin is a predictor of differentiation and nodal metastases. Even if the difference between VEGF expression and tumor stage was not statistically significant, it seems that there exists some relationship, which might be clarified with a greater number of cases.