Araştırma Çıktıları

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    Olfactory Bulb MRI and Paranasal Sinus CT Findings in Persistent COVID-19 Anosmia
    (ELSEVIER SCIENCE INC, 2021-01-01) Kandemirli, Sedat Giray; Altundag, Aytug; Yildirim, Duzgun; Sanli, Deniz Esin Tekcan; Saatci, Ozlem
    Background and purpose: There is limited literature consisting of case reports or series on olfactory bulb imaging in COVID-19 olfactory dysfunction. An imaging study with objective clinical correlation is needed in COVID-19 anosmia in order to better understand underlying pathogenesis. Material and methods: We evaluated 23 patients with persistent COVID-19 olfactory dysfunction. Patients included in this study had a minimum 1-month duration between onset of olfactory dysfunction and evaluation. Olfactory functions were evaluated with Sniffin' Sticks Test. Paranasal sinus CTs and MRI dedicated to olfactory nerves were acquired. On MRI, quantitative measurements of olfactory bulb volumes and olfactory sulcus depth and qualitative assessment of olfactory bulb morphology, signal intensity, and olfactory nerve filia architecture were performed. Results: All patients were anosmic at the time of imaging based on olfactory test results. On CT, Olfactory cleft opacification was seen in 73.9\% of cases with a mid and posterior segment dominance. 43.5\% of cases had below normal olfactory bulb volumes and 60.9\% of cases had shallow olfactory sulci. Of all, 54.2\% of cases had changes in normal inverted J shape of the bulb. 91.3\% of cases had abnormality in olfactory bulb signal intensity in the forms of diffusely increased signal intensity, scattered hyperintense foci or microhemorrhages. Evident clumping of olfactory filia was seen in 34.8\% of cases and thinning with scarcity of filia in 17.4\%. Primary olfactory cortical signal abnormality was seen in 21.7\% of cases. Conclusion: Our findings indicate olfactory cleft and olfactory bulb abnormalities are seen in COVID-19 anosmia. There was a relatively high percentage of olfactory bulb degeneration. Further longitudinal imaging studies could shed light on the mechanism of olfactory neuronal pathway injury in COVID-19 anosmia.
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    The role of PET and MRI in evaluating the feasibility of skin-sparing mastectomy following neoadjuvant therapy
    (SAGE PUBLICATIONS LTD, 2018-01-01) Malya, Fatma Umit; Kadioglu, Huseyin; Bektasoglu, Huseyin Kazim; Gucin, Zuhal; Yildiz, Seyma; Guzel, Mehmet; Erdogan, Ezgi Basak; Yucel, Serap; Ersoy, Yeliz Emine
    Objective To investigate the role of positron emission tomography (PET) and magnetic resonance imaging (MRI) in evaluating the feasibility of skin-sparing mastectomy in patients with locally-advanced breast cancer (LABC) who will undergo neoadjuvant chemotherapy (NAC) by evaluating the sensitivity and specificity of PET and MRI compared with skin biopsy results before and after NAC treatment. Methods Patients with LABC who were treated with NAC between November 2013 and November 2015 were included in this study. Demographic, clinical, radiological and histopathological features of the patients were recorded. Results A total of 30 patients were included in the study with a mean age of 52.6 years (range, 35-70 years). Sensitivity and specificity for detecting skin involvement in LABC was 100\%/10\% (62\%/85\%) with MRI and 60\%/80\% (12\%/92\%) with PET before (after) NAC, respectively. When radiological skin involvement was assessed in relation to the final histopathological results, the preNAC PET results and histopathological skin involvement were not significantly different