Araştırma Çıktıları

Permanent URI for this communityhttps://hdl.handle.net/11443/931

Browse

Subject: search.filters.subject.Acromegaly

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    LONGER CECUM INSERTION TIME AND MORE INADEQUATE COLONIC PREPARATION IN PATIENTS WITH ACROMEGALY: IS A DIFFERENT COLONOSCOPY PREPARATION NEEDED?
    (EDITURA ACAD ROMANE, 2017-01-01) Caglar, E.; Hatipoglu, E.; Atasoy, D.; Niyazoglu, M.; Caglar, A. S.; Tuncer, M.; Dobrucali, A.; Kadioglu, P.
    Purpose. To investigate whether there is a difference between acromegalic and non-acromegalic cases in terms of bowel preparation and colonoscopic intervention. Methods. Patients with controlled and uncontrolled acromegaly and as a control group (CG) patients without acromegaly between January 2010 and March 2014 were included. Groups were compared regarding adequacy of bowel preparation, cecal insertion time (CIT) and colonoscopy results. Results. Fifty-nine patients with acromegaly (controlled n=30, uncontrolled n=29) and 73 age and gender matched volunteers without acromegaly were evaluated. CIT in cases with controlled, uncontrolled acromegaly cases and in CG was 5.33 {[}4.00-6.00], 7.00 {[}4.91-11.31], and 3.10 {[}2.35-4.65] minutes, respectively (p<0.001). Cases in CG had shorter CIT compared to controlled and uncontrolled acromegaly cases ( p=0.014 and p<0.001, respectively). There was no significant difference regarding CIT between controlled and uncontrolled acromegaly cases (p=0.247). Six (20\%) of controlled acromegaly patients, 10 (35\%) of uncontrolled acromegaly patients and three (4\%) of CG had inadequate bowel cleansing (p<0.001). Although statistically insignificant, cases with inadequate bowel cleansing had tendency towards having prolonged CIT in comparison to cases with adequate bowel cleansing (6.00 {[}3.87-9.00] and 4.16 {[}2.95-5.70] minutes, respectively, p=0.07). Conclusion. Inadequate bowel cleansing is one of the main problems encountered during colonoscopic investigation/surveillance in acromegalic patients. Therefore, a different protocol for colonoscopy preparation may be needed for these cases.
  • Thumbnail Image
    Item
    Obstructive Sleep Apnea Syndrome in Acromegaly Before and After Treatment
    (GALENOS PUBL HOUSE, 2014-01-01) Korkmaz, Selda; Cakir, Ilkay; Bayram, Fahri; Karaca, Zuleyha; Ismailogullari, Sevda; Aksu, Murat
    Introduction: Obstructive sleep apnea syndrome (OSAS) prevalence in acromegaly patients is very common compared with general population. It is thought that OSAS in acromegaly patients evolve because of reversible and irreversible anatomical changes. However, reason of anatomical changes has not been known in present. Maybe, Growth Hormone (GH) and insulin-like growth factor 1 (IGF-I) levels could be an important factor in the development of anatomical changes. In this study, we aimed to determine the prevalence of OSAS in acromegaly and to show the correlation between disease activity and OSAS in acromegalic patients. Materials and Methods: Newly diagnosed and treatment naive 15 acromegaly patients were included into the study. Patients were evaluated by polysomnography (PSG) recordings and hormone levels at baseline and 6 months after treatment. Results: Present study showed that OSAS is more common in patients with acromegaly than general population. Moreover, there is no correlation between GH, IGF-I level and apnea-hipopnea index (AHI) both at baseline and 6 months after treatment. Discussion: OSAS is a condition increased morbidity and mortality associated with acromegaly. Early diagnosis and treatment of acromegaly is important in order to prevent progression of anatomical changes leading to OSAS to an irreversible state. If OSAS and its complications had been prevented, morbidity and mortality in acromegaly patients would have been decreased.