Araştırma Çıktıları

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    Gut immune homeostasis: the immunomodulatory role of Bacillus clausii, from basic to clinical evidence
    (TAYLOR \& FRANCIS LTD, 2022-01-01) Wong-Chew, Rosa Maria; de Castro, Jo-Anne A.; Morelli, Lorenzo; Perez, Marcos; Ozen, Metehan
    Introduction The gut microbiota affects the development of the gut immune system in early life. Perturbations to microbiota structure and composition during this period can have long-term consequences on the health of the individual, through its effects on the immune system. Research in the last few decades has shown that probiotic administration can reverse these effects in strain- and environment-specific ways. Bacillus clausii (B. clausii) has been in use for many decades as a safe and efficacious probiotic, but its mode of action has not yet been completely elucidated. Areas covered In this review, we discuss how the gut immune system works, the factors that affect its functioning, and the plethora of research highlighting its role in various diseases. We also discuss the known modes of action of Bacillus probiotics, and highlight the preclinical and clinical evidence that reveal how B. clausii acts to bolster gut defense. Expert opinion We anticipate that the treatment and/or prevention of dysbiosis will be central to managing human health and disease in the future. Discovering the pathophysiology of autoimmune diseases, infections, allergies, and some cancers will aid our understanding of the key role played by microbial communities in these diseases.
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    Possible Risk Factors Associated with Allergic Diseases Among Perinatal and Infancy Period
    (AVES, 2019-01-01) Aktas, Selma; Say, Aysu
    Objective: The aim of the study was to investigate perinatal and early-chihdood risk factors which facilitate development of allergic diseases. Methods: This study was held between the years 2009-2010 among allergic children (n=188) aged 1-16 years, followed in the Allergy Immunology outpatient clinic. The control group was composed of healthy chidren of healthcare personnel and healthy children followed in the outpatient clinic (n=72). A survey which examined the risk factors associated with asthma, allergic rhinitis, atopic dermatitis and urticaria-angioedema was used. Results: The number of male children in the case and control group was 106 (56.4\%) and 37 (48.6\%), respectively. The mean age of case and control group was 7.73 +/- 3.31 and 7.06 +/- 2.86 years, respectively. The mean age of patients diagnosed atopic dermatitis, asthma and allergic rhinitis was 1.77 +/- 1.30