Araştırma Çıktıları
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Item Relationship between disease severity and serum IL-6 levels in COVID-19 anosmia(W B SAUNDERS CO-ELSEVIER INC, 2021-01-01) Sanli, Deniz Esin Tekcan; Altundag, Aytug; Kandemirli, Sedat Giray; Yildirim, Duzgun; Sanli, Ahmet Necati; Saatci, Ozlem; Kirisoglu, Ceyda Erel; Dikensoy, Oner; Murrja, Edvin; Yesil, Atakan; Bastan, Serdar; Karsidag, Tamer; Akinci, Ibrahim Ozkan; Ozkok, Sezen; Yilmaz, Eren; Tuzuner, Filiz; Kilercik, Meltem; Ljama, TanerBackground: An association between IL-6 levels and cytokine storm syndrome in COVID-19 patients has been suggested. Cases with higher IL-6 levels have more rapid progression and a higher complication rate. On the other hand, COVID-19 cases with anosmia have a milder course of the disease. Objective: We aimed to investigate whether there is a relationship between serum IL-6 levels and presence of anosmia in COVID-19 patients. Methods: Patients with a confirmed diagnosis of COVID-19 based on laboratory (PCR) were stratified into two groups based on presence of olfactory dysfunction (OD). In all cases with and without anosmiaItem Computed tomography based evaluation of prostatic fiducial marker migration between the periods of insertion and simulation(AVES, 2017-01-01) Arpaci, Taner; Ugurluer, Gamze; Ispir, Emine Burcin; Eken, Alper; Akbas, Tugana; Serin, MeltemObjective: The aim of this study was to determine whether significant fiducial marker migration occurs between the periods of prostatic marker insertion and computed tomography (CT) performed for radiotherapy planning and if a waiting period is necessary. Material and methods: Thirty-nine patients with prostate adenocarcinoma underwent fiducial marker insertion before radiotherapy between June 2013 and December 2015. Three markers were inserted by one radiologist under the guidance of transrectal ultrasonography. All patients underwent CT three hours after insertion to confirm the number and position of fiducial markers. Radiotherapy planning CT was performed on an average of 11 days (range 7-20) after insertion. CT images were imported into treatment planning system to analyze the position of fiducial markers. Point-based marker match algorithm was used to find the distance of marker migration. The mean and maximum distances between each fiducial markers were calculated. Results: The mean distance of migration was 1.029+/-0.42 mm (range 0.23-1.93 mm) and the maximum distance was 1.361+/-0.59 mm (range 0.25-2.74 mm). The distance of marker migration was not statistically significant for the groups organized according to the timing of marker insertion, prostate volume, patient age, prostate specific antigen level and Gleason score. Conclusion: According to our results significant fiducial marker migration did not occur during the interval between insertion and treatment planning CT. It should be taken into consideration that performing simulation on the same day as marker insertion might prevent increased cost and delayed radiation therapy by saving the patients from extra visits to the clinic.Item Morphometric Characteristics of C1-C2 Vertebrae to Perform Anterior Transarticular Crossing Screw Fixation(TURKISH NEUROSURGICAL SOC, 2018-01-01) Tun, Kagan; Cemil, Berker; Gokce, Emre CemalAIM: In unique clinical situations where C1-C2 posterior fixation is not available or has previously failed, an anterior transarticular screw (ATAS) may be a viable alternative. However, there are no previous reports that investigate possible screw angles, screw entry points, and screw length based on computed tomography (CT) multiplanar reconstruction images in Turkish patients. The aim of this study was to determine the morphometric characteristics C1-C2 vertebrae in order to perform anterior transarticular crossing screw fixation. MATERIAL and METHODS: Patients who underwent a complete CT scan of the cervical spine for causes other than an investigation of cervical spine malformation or congenital anomaly between the years 2013 and 2015 were included in this study. The anterior transarticular C1-C2 screw angles, screw entry point, and screw length were measured on coronal and sagittal CT multiplanar reconstruction images. RESULTS: Twenty-five male and 14 female patients were included in the study. The mean maximum screw angle for ATAS was found to be 41.18 degrees +/- 4.49 degrees. The minimum and maximum screw lengths were 27.46 +/- 3.39 mm and 28.46 +/- 3.60 mm, respectively. CONCLUSION: Preoperatively, performing a calculation of the possible screw angles, screw entry point, and screw length based on CT multiplanar reconstruction images for ATAS is a safe and applicable method. In cases in which ATAS fixation across the atlantoaxial joint procedure should be performed without performing a measurement, a screw angle not more than 41.18 degrees +/- 4.49 degrees on the coronal plane does not damage the vertebral artery. Furthermore, using screws shorter than 28.46 +/- 3.60 mm doesn't purchase the atlantoaxial joint.