Araştırma Çıktıları

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Subject: search.filters.subject.Infertility

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    Fertility-sparing in cancer patients
    (IMR PRESS, 2021-01-01) Karakas, Sema; Kaya, Cihan; Schafer, Sebastian Daniel; Mikus, Mislav; Terzic, Milan; Abdullaev, Bekhzod; Andrisani, Alessandra
    Objective: This review aimed to investigate and summarize the current evidence on fertility-sparing options in cancer patients. Mechanism: Fertility preservation methods are becoming popular through the improved prognosis of cancer patients at a younger age and early diagnostic tools. However, currently, more and more women are suffering from iatrogenic ovarian failure and fertility loss because of cancer treatment. Most treatments have been used for hematological malignancies, but different gynecological cancers can be eligible. Findings in brief: Fertility preserving strategies such as oocyte and embryo cryopreservation, ovarian tissue preservation, ovarian transposition, and aspiration of ovarian follicles are the methods that could be suggestedto the patients. The current knowledge supports oocyte and embryo cryopreservation as feasible, safe, and effective treatment approaches for cancer patients seeking fertility preservation. Conclusions: Robust evidence is still needed to prove the effectiveness of cryopreservation of the ovarian tissue and ovarian follicle aspiration approaches since these techniques are still in early their steps.
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    Differential gene expression analysis of human cumulus cells
    (KOREAN SOC REPRODUCTIVE MEDICINE, 2019-01-01) Demiray, Sirin Bakti; Goker, Ege Nazan Tavmergen; Tavmergen, Erol; Yilmaz, Ozlem; Calimlioglu, Nilufer; Soykam, Huseyin Okan; Oktem, Gulperi; Sezerman, Ugur
    Objective: This study was performed to explore the possibility that each oocyte and its surrounding cumulus cells might have different genetic expression patterns that could affect human reproduction. Methods: Differential gene expression analysis was performed for 10 clusters of cumulus cells obtained from 10 cumulus-oocyte complexes from 10 patients. Same procedures related to oocyte maturation, microinjection, and microarray analyses were performed for each group of cumulus cells. Two differential gene expression analyses were performed: one for the outcome of clinical pregnancy and one for the outcome of live birth. Results: Significant genes resulting from these analyses were selected and the top 20 affected pathways in each group were analyzed. Circadian entrainment is determined to be the most affected pathway for clinical pregnancy, and proteoglycans in cancer pathway is the most affected pathway for live birth. Circadian entrainment is also amongst the 12 pathways that are found to be in top 20 affected pathways for both outcomes, and has both lowest p-value and highest number of times found count. Conclusion: Although further confirmatory studies are necessary, findings of this study suggest that these pathways, especially circadian entrainment in cumulus cells, may be essential for embryo development and pregnancy.
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    Pregnancy success rate at recurrent implantation failure patients after hysteroscopic endometrial injury: preliminary study
    (7847050 CANADA INC, 2019-01-01) Aydeniz, E. G.; Sari, U.; Dilek, T. U. K.
    Purpose of Investigation: To assess better implantation and pregnancy rates following endometrial injury in the presence of previous implantation failure, through a retrospective study in a tertiary University Clinic. The aim of this study is to assess improved embryo implantation after hysteroscopic fundal endometrial injury in repeated implantation failure in patients. Materials and Methods: Twenty-nine women who had recurrent implantation failure participated in the study. They had three or more implantation failures with good quality embryo. Anti-Mullerian hormone (AMH) levels, age, antral follicle count, body mass index, and FSH levels were collected. Frozen/thawed embryos (FTE) were transferred in all subjects. Before embryo transfer the authors performed hysteroscopic endometrial injury by micro cold knife. Results: Median age was 38.62 +/- 2.47 years in the study. AMH levels changed between 0.35 and 3.8 ng/ml. The pregnancy rate following hysteroscopy: 17 (58,6\%) were pregnant and 12 of 29 subjects did not become pregnant. The women who became pregnant following hysteroscopy were younger and had a higher antral follicle count than the non-pregnant women (p = 0.030 and p = 0.0017 respectively