Araştırma Çıktıları

Permanent URI for this communityhttps://hdl.handle.net/11443/931

Browse

Subject: search.filters.subject.Multiple sclerosis

Search Results

Now showing 1 - 4 of 4
  • No Thumbnail Available
    Item
    The Socioeconomic and Psychological Impact of the COVID-19 Pandemic on People with Multiple Sclerosis in Turkey
    (TURKISH NEUROPSYCHIATRY ASSOC-TURK NOROPSIKIYATRI DERNEGI, 2022-01-01) Gunduz, Tuncay; Uzunkopru, Cihat; Demir, Serkan; Tutuncu, Melih; Seferoglu, Meral; Gumus, Haluk; Sen, Sedat; Gungor Dogan, Ipek; Tutuncu, Mesude; Solak Calikoglu, Yasemin; Beckmann, Yesim; Sagduyu Kocaman, Ayse; Siva, Aksel
    Introduction: Various restrictions due to the coronavirus infection have affected working life globally. People with multiple sclerosis (pwMS) have several difficulties in social life, patient follow-up, and receiving treatments. In this study, we aimed to evaluate the experiences of pwMS during the COVID-19 pandemic. Method: We developed a 50-question survey aiming to determine fears, anxieties, and the problems experienced by patients regarding their diseases and social lives during the COVID-19 pandemic. The questionnaire was released online via the Turkish MS Society website, local MS societies websites, and social media accounts. Only the answers of the patients who filled out the questionnaire completely were evaluated. Results: In total, 6008 patients took the survey, and 3255 of them completed the questionnaire. Among all, 378 patients (11.6\%) were positive for COVID-19. The most common COVID-19-related symptom was fatigue (48.4\%). The routine medical follow-up was interrupted in 61.4\% and the medication was discontinued in 14\% of the patients. Approximately 25\% of the patients reported different symptoms related to relapse activity. The main concern of the patients related to the COVID-19 pandemic was the disruption of the health of the ones they loved. Among all the patients, 4.4\% lost their jobs. Conclusion: Our data showed that the COVID-19 pandemic strongly affected the working lives of pwMS. Also, the pandemic changed the attitudes of patients and neurologists. Therefore, the long-term effects of the COVID-19 pandemic on disease approach, patient follow-up, social conditions, and working life should be monitored.
  • No Thumbnail Available
    Item
    Differences Between General Neurologists and Multiple Sclerosis Specialists in the Management of Multiple Sclerosis Patients: A National Survey
    (AVES, 2019-01-01) Kurtuncu, Murat; Tuncer, Asli; Uygunoglu, Ugur; Caliskan, Zeynep; Kokenli Paksoy, Aysenur; Efendi, Husnu; Sagduyu Kocaman, Ayse; Ozcan, Cemal; Terzi, Murat; Turan, Omer Faruk; Saip, Sabahattin; Karabudak, Rana; Siva, Aksel
    Introduction: The management of multiple sclerosis (MS) has become more complicated after the introduction of new diagnostic and treatment options. Despite the abundance of guidelines, the experience of physicians still plays a major role in the management of patients. This study aimed to define differences in behavior patterns between general neurologists (GNs) and MS specialists (MSSs). Methods: We conducted a survey of 36 questions to 318 neurologists, including 33 MSSs. The survey covered topics including laboratory investigations, pregnancy, and treatment. Results: Our study found many differences between GNs and MSSs in terms of management, the most important being treatment initiation and switching. GNs had a tendency to initiate treatment later than MSSs however, they tended to switch treatment faster. Our study also showed that GNs ordered magnetic resonance imaging (MRI) more frequently than MSSs, even if patients were clinically stable. Moreover, although GNs more frequently relied on MRI, they did not consider brain atrophy as an important measure in the follow-up of their patients. Furthermore, GNs considered replacement therapy less often than MSSs, even in patients with vitamin D deficiency. Discussion: Our study revealed important discrepancies between the management patterns of GNs and MSSs in MS patients. These findings suggest the need for a national education program for GNs on MSSs.
  • No Thumbnail Available
    Item
    Investigation of multiple sclerosis-related pathways through the integration of genomic and proteomic data
    (PEERJ INC, 2021-01-01) Everest, Elif; Ulgen, Ege; Uygunoglu, Ugur; Tutuncu, Melih; Saip, Sabahattin; Sezerman, Osman Ugur; Siva, Aksel; Turanli, Eda Tahir
    Background. Multiple sclerosis (MS) has a complex pathophysiology, variable clinical presentation, and unpredictable prognosis
  • Thumbnail Image
    Item
    The Diagnostic and Prognostic Value of Magnetic Resonance Imaging for Evaluating Atypical Inflammatory Demyelinating Lesions
    (TURKISH NEUROLOGICAL SOC, 2021-01-01) Ozdemir, Zeynep; Acar, Erkan; Soysal, Aysun
    Objective: The diagnosis of patients with atypical demiyelinating lesions has always been challenging, sometimes leading to a biopsy. Recent literature has radiologically classified atypical inflammatory demyelinating lesions as ring-like, Balo-like, infiltrative, megacystic, and unclassified lesions. In this study, we aimed to assess the demographics and clinical and radiologic findings in patients with atypical lesions. Materials and Methods: The records of 320 patients with demyelinating disorders were retrospectively assessed using iMed database. Patients with atypical lesions and whose magnetic resonance imaging evaluations were included. Clinical and radiologic findings were evaluated and lesions were classified according to the recommended criteria. Results: Twenty-seven patients (16 females) were included and the mean age was 34.26 +/- 6.12 (range: 26-49) years. Fourteeen patients had ring-like, three had Balo-like, three had megacystic, five had infiltrative, and two patients had unclassified lesions. Diffusion restriction was observed in contrast-enhancing sites in ring-like lesions, heterogeneously in infiltrative lesions and also peripherally in Balo-like lesions. Two patients with infiltrative lesions had additional lesions on follow-up and had to undergo biopsy. Two patients died despite aggressive treatment. Two patients with Balo-like lesions were evaluated as having acute disseminated encephalomyelitis and did not have further relapses. Seventeen patients from the study group converted to multiple sclerosis (MS) on follow-up. Conclusion: Differential diagnosis of atypical inflammatory demyelinating lesions is not always easy, the prognosis is not different from MS lesions. Mostly, ringlike lesions seem to convert to MS with recurrent relapses