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    COMPARISON OF SLEEP MACRO- AND MICROSTRUCTURES IN ELDERLY AND MIDDLE-AGED MALE PATIENTS WITH SEVERE OBSTRUCTIVE SLEEP APNEA: DOES THE DISEASE ERASE DIFFERENCES?
    (GUNES KITABEVI LTD STI, 2020-01-01) Huseyinoglu, Nergiz; Kose Ozlece, Hatice; Ardic, Sadik
    Introduction: Age-related changes in sleep attract increased attention from researchers and are studied in the context of micro- and macrostructures. Macrostructures include sleep onset, total sleep time, sleep efficiency, wake time after sleep onset, and non-rapid eye movement and rapid eye movement sleep percentages, latencies and durations. Sleep microstructures refer to a cyclic alternating pattern.The present study aims to investigate how sleep structures in older and middle-aged patients are affected by the widespread disease of obstructive sleep apnea. The authors believe that it provide additional information about sleep disorder pathogenesis. Materials and Method: Patients who received a diagnosis of severe sleep apnea were divided into two groups: age >= 65 years old and 35-45 years old. Macro-and microstructural data from polysomnographic investigations were collected and compared. Results: There were no statistically significant differences for total sleep time, sleep efficiency, wake time after sleep onset, rapid eye movement sleep latency and separate percentages of non-rapid eye movement sleep stages N1, N2 and N3. Regarding sleep microstructures, there were no differences between arousal index, cyclic alternating pattern rates, or percentage ratio of phase subtype. Conclusion: The parameters of the macro- and microstructures in the older group are similar to those of the middle-aged group and are also basically similar to the parameters of previous studies
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    Understanding sleep problems in children with epilepsy: Associations with quality of life, Attention-Deficit Hyperactivity Disorder and maternal emotional symptoms
    (W B SAUNDERS CO LTD, 2016-01-01) Ekinci, Ozalp; Isik, Ugur; Gunes, Serkan; Ekinci, Nuran
    Purpose: This study aimed to (1) compare sleep problems between children and adolescents with epilepsy and non-epileptic controls, and (2) examine whether there is an association between sleep problems and quality of life, Attention-Deficit Hyperactivity Disorder (ADHD) and mothers' emotional symptoms. Method: Fifty-three patients from a cohort of epilepsy (aged 7-18 years) and 28 controls with minor medical problems (aged 7-18 years) were included. Parents completed Children's Sleep Habits Questionnaire (CSHQ) and Kinder Lebensqualitatsfragebogen: Children's Quality of Life Questionnaire revised (KINDL-R) for patients and controls.Turgay DSM-IV Disruptive Behavior Disorders Rating Scale (T-DSM-IV-S) parent and teacher forms were used to assess ADHD symptoms for patients. Mothers of the patients completed Beck Depression Inventory and State-Trait Anxiety Inventory (STAI). Neurology clinic charts were reviewed for the epilepsy-related variables. Results: Children with epilepsy had a higher CSHQ Total score than the control group. Those with a CSHQ score >56 (which indicates moderate to severe sleep problems) had lower scores on KINDL-R. Parent rated T-DSM-IV-S Total and Hyperactivity-Impulsivity scores, STAI trait and Beck scores were found to be higher in those with a CSHQ score >56. Significant positive correlations were found between CSHQ Total score and T-DSM-IV-S, STAI trait and Beck scores. Binary logistic regression analysis revealed that T-DSM-IV-S Total, Inattention and Hyperactivity-Impulsivity scores were significantly associated with a higher CSHQ Total score. None of the epilepsy-related variables were found to be related with the CSHQ Total score. Conclusion: Among children with epilepsy, sleep problems lead to a poor quality of life. The link between sleep problems and psychiatric symptoms must be conceptualized as a bilateral relationship. ADHD appears to be the strongest predictor of sleep problems. (C) 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.