Araştırma Çıktıları

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    Ischemia-modified albumin and the IMA/albumin ratio in the dignosis and staging of hemorrhagic shock: A randomized controlled experimental study
    (TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2020-01-01) Turedi, Suleyman; Sahin, Aynur; Akca, Metehan; Demir, Selim; Kose, Gokcen Derya Reis; Cekic, Arif Burak; Yildirim, Mehmet; Yulug, Ersin; Mentese, Ahmet; Turkmen, Suha; Acar, Sami
    BACKGROUND: To determine the value of ischemia-modified albumin (IMA) and IMA/albumin ratio (IMAR) in the diagnosis and staging of hemorrhagic shock (HS). METHODS: A pressure-targeted HS model was established in this study. The control and shock groups were monitored for 30 min and 60 min to simulate varying durations of exposure to HS. All subjects underwent invasive arterial monitoring during the experiment and were further divided into mild and severe shock groups based on decreases in mean arterial pressure (MAP). Biochemical and histologic comparisons were performed between the groups. RESULTS: Our results revealed higher IMA, IMAR, lactate, total oxidant status (TOS) and oxidative stress index (OSI) levels in both the 30- and 60-min shock groups compared to the control group. Concerning MAP-based shock staging, IMA, IMAR, lactate, TOS and OSI levels in the 30-min and 60-min mild and severe shock groups were higher than those of the controls. However, there was no significant difference between the mild and severe shock groups. A significant correlation was determined between all the biomarkers evaluated and HS-induced damage in various organs. This correlation was highest in lactate and IMAR levels. CONCLUSION: IMA and IMAR levels may be used in the early diagnosis of HS and also have the potential for use in determining the severity of HS. IMA and IMAR measurement may also be considered as an alternative or in addition to lactate measurement in the diagnosis of HS.
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    Spontaneous Retroperitoneal Hemorrhage Due to Chromophobic Type Renal Cell Carcinoma Requiring Emergency Action: Case Report
    (ORTADOGU AD PRES \& PUBL CO, 2012-01-01) Coskuner, Enis Rauf; Ozkan, Burak; Yalcin, Veli
    Spontaneous retroperitoneal hemorrhage is a quite rare disease. Appropriate treatment should be done after the cause of the disease had been detected. A complete clinical information and detailed radiologic examination are required for accurate diagnosis. In this study, a 76-year-old female patient who was evaluated in the emergency department of our hospital and found to have an abruptly developed retroperitoneal hemorrhage and hemorrhagic shock due to a big renal mass is presented. The patient required immediate radical nephrectomy. Pathological diagnosis was chromophobe type renal cell carcinoma with an invasion into the perinephric fat (pT3a). Subsequent staging after the operation failed to indicate any metastaic disease and there was no local or distant metastates in the first year follow-up.