Araştırma Çıktıları

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Subject: search.filters.subject.laryngeal cancer

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    Predictive Values of Systemic Inflammation Index in Prognosis of Patients with Laryngeal Cancer
    (KARE PUBL, 2020-01-01) Demir, Atakan; Alan, Ozkan; Surmeli, Mehmet
    Objectives: Laryngeal cancer is the most common cancer in head and neck cancer group, of which it constitutes 75\%. Squamous cell carcinoma (SCC) is the most common histological subtype. Systemic or local inflammation is a well known promotor for cancer development and progression. Systemic immune inflammation index (S II) has been reported as an independent prognostic parameter in various cancers. We aimed to evaluate the capability of SII in predicting the risk of recurrence in patients with operable laryngeal cancer. Methods: We retrospectively collected the data of 100 laryngeal SCC patients who underwent surgery between 2016 and 2018. Neutrophil, lymphocyte, and platelet (Plt) counts were recorded. The SII was calculated as follows: SII= Neutrophile counts {*}platelet counts/lymphocyte counts. Results: SI index was found to be an independent prognostic factor as affecting disease recurrence (p<0.05). We found that patients with SII >891 had a risk of disease recurrence of approximately three times more than patients with SII = <891.78 (HR: 3.06 (95\% CI: 3.42-132.64). Conclusion: This was the first study to demonstrate that preoperative SI index is a simple and powerful independent predictive index that predicts the risk of disease recurrence in patients with laryngeal cancer.
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    The Effects of Adjuvant Chemoradiotherapy on Survival in Patients with Primary Laryngeal Cancer with Close Surgical Margins and Positive Surgical Margins
    (KARE PUBL, 2020-01-01) Inanc, Berrin; Inanc, Kubilay; Bilici, Suat; Cakir, Mustafa; Yigit, Ozgur
    OBJECTIVE The gold standard treatment for squamous cell carcinoma of the larynx is a resection of the primary tumour with negative surgical margins. In this study, we retrospectively investigated the effects of adjuvant concurrent chemoradiation on the survival rates of laryngeal cancer with close surgery margins and patients with positive surgery margin. METHODS A total of 40 patients treated with concurrent chemoradiation were included in this study. All of these patients had surgery for laryngeal cancer and had received 66 Gy (2Gy/fr) of radiotherapy and concurrent weekly cisplatin. Patients were stratified into two groups according to surgical margin status. Members of group 1 had a positive surgery margin
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    Post Endolaryngeal Laser Surgery Carbon Granuloma
    (GALENOS YAYINCILIK, 2017-01-01) Ertas, Burak; Emre, Ismet Emrah; Aksoy, Elif; Ulubil, Arif; Guven, Melih Guven; Tanyeri, Hasan; Unal, Omer Faruk
    Aim: This study was performed to highlight the phenomenon of carbon granulation formation after laser vocal cord surgery. Emphasis was put on the fact that these granulomas closely resemble tumor recurrence and due to the similarity of appearance, histological evaluation is necessary for diagnosis. Methods: This study included 35 male patients presenting to the Acibadem University Hospital with early-stage laryngeal cancer between 2009 and 2013. All patients underwent laser-assisted interventions on the vocal cords. Patient follow-up was continued for two years and granuloma formation or tumor recurrence was noted. Results: During the two-year follow-up period, a total of five patients presented with new vocal cord lesions. One of the cases was determined to be a tumor recurrence. The remaining four were carbon granulomas that regressed during the follow-up period. Conclusion: Although carbon granuloma formation is not very common, it is still frequent enough to be thoroughly discussed in the literature. With laser surgery for early-stage laryngeal cancer becoming more popular every day, the incidence of carbon granulomas is likely to increase. An algorithm for this type of lesion without putting patients' health at risk will be a valuable tool in the near future.