Araştırma Çıktıları
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Item The close relation of tic disorders with childhood migraine and atopic background of both children and mothers(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2020-01-01) Aksu, Gulen Guler; Kutuk, Meryem Ozlem; Tufan, Ali Evren; Toros, Fevziye; Uluduz, Derya; Ozge, AynurObjective: This study aimed to evaluate primary headache disorders and other causative comorbidities (e.g., epilepsy, atopic disorders, recurrent abdominal pain, motion sickness, and headache) in children with tic disorders (TDs) and their mothers. Materials and Methods: In a multi-center, cross-sectional, familial association study using case-control design, youth (between 7 and 17 years) with TDs (TD, as per Diagnostic and Statistical Manual of Mental Disorders-5 criteria) and age- and sex-matched healthy controls and their mothers were evaluated in the aspect of functional syndromes spectrum including migraine, epilepsy, atopic disorders, motion sickness, and recurrent abdominal pain. Results: Seventy-nine youth with TD and 101 controls were included. Causative comorbidities, other than epilepsy and motion sickness were more common in children with TD with an odds ratio (OR) of 2.1 (atopy) and 3.9 (food allergy). Specifically, recurrent abdominal pain and migraine were found in 36.7\% and 31.7\% of children (vs. 18.8\% and 16.8\% of controls, ORs 2.5 and 2.3, respectively). Mothers of youth with TDs also have higher rates of atopy, drug allergy and allergic dermatitis (ORsItem Reliability and Validity of Turkish Version of Headache Impact Test (HIT-6) in Patients with Migraine(TURKISH NEUROPSYCHIATRY ASSOC-TURK NOROPSIKIYATRI DERNEGI, 2021-01-01) Yalinay Dikmen, Pinar; Bozdag, Mumine; Gunes, Mumin; Kosak, Seda; Tasdelen, Bahar; Uluduz, Derya; Ozge, AynurIntroduction: The Headache Impact Test (HIT-6) is a self-report questionnaire designed to evaluate the impact of headache on quality of life. The aim of this study is to assess reliability and validity of Turkish version of HIT-6 questionnaire in patients with migraine. Methods: A total of 114 patients with migraine were included in this multicenter, prospective, descriptive study conducted at two consecutive visits 4 weeks apart. Comprehensibility, patient-physician reliability, internal consistency, test-retest reliability and validity of the translated HIT-6 were analyzed. Results: Patients identified that HIT-6 items were ``well-understood{''} in both visit 1 (ranged from 88.6\% to 95.7\%) and visit 2 (ranged from 93.0\% to 98.2\%). A highly positive correlation (R=0.876, p<0.001) was noted between visit 1 scores related to self-administered and physician-administered HIT-6 scores. Internal consistency analyzed via Cronbachs alpha values for visit 1 and visit 2 HIT-6 scores in all patients were 0.753 (acceptable) and 0.864 (excellent), respectively. HIT-6 scores of patients (64.13 (6.20) and 62.70 (7.04), at visits 1 and 2, respectively, p=0.07) showed a moderate test-retest reliability (R=0.437, p=0.0004). The HIT-6 score positively correlated with visit 1 and visit 2 headache severity-Likert scale (R=0.451 and 0.478, respectively, p<0.001) and VAS (R=0.365 and 0.531, respectively p<0.001) scores, and with visit 2 headache days for a month (R=0.215, p=0.022). Conclusion: These results demonstrated that the Turkish translation is equivalent to English version of HIT-6 in terms of internal consistency and it has moderate test-retest reliability and validity as correlated with headache severity, VAS and headache days for a month.Item Evaluation of video head impulse test during vertiginous attack in vestibular migraine(PACINI EDITORE, 2022-01-01) Koc, Ahmet; Akkilic, Elvan CevizciObjective. The aim of this study is to evaluate vestibular functions with video head impulse test (VHIT) and to understand the value of VHIT in differential diagnosis in patients with vestibular migraine (VM) during dizziness attack. Materials and methods. Two groups were enrolled in this study. The first consisted of 84 vestibular migraine patients, and second group of 74 healthy subjects. VHIT was applied to patients with VM during vertigo attack and the results were compared with the VHIT values applied to subjects in the control group. Results. The mean vestibulo-ocular reflex (VOR) in all semicircular canals in the VM group was lower than healthy individuals, but the results were not statistically significant. Refixa-tion saccades were found in 52.3\% of VM patients and in 10.2\% of healthy individuals. Conclusions. When patients with VM were evaluated with VHIT during vertiginous attack, VOR gain values were not different from healthy individuals, but the number of catch-up saccades were higher in VM patients, which indicates peripheral vestibular involvement. For differential diagnosis in patients with VM, vestibular tests should be performed dur-ing the vertigo attack. When evaluating VHIT results, the presence of refixation saccades should also be evaluated.Item The effect of migraine and motion sickness on symptoms evoked by the caloric vestibular test(IOS PRESS, 2022-01-01) Gedik-Soyuyuce, Ozlem; Yalinay-Dikmen, Pinar; Korkut, NazimBACKGROUND: The caloric vestibular test (CVT) may evoke headache and vestibular symptoms in susceptible people. Patients with migraines have higher susceptibility to motion sickness. In migraines, impaired habituation to repetitive stimuli is a well-known interictal abnormality. OBJECTIVE: This study is aimed at evaluating CVT-evoked headache, nausea, vomiting, and imbalance in patients with and without migraine and/or motion sickness. METHODS: A retrospective data analysis was performed on 554 patients with a complaint of dizziness who underwent bithermal CVT at a tertiary referral center. The occurrences of CVT-evoked headache, nausea, vomiting, and imbalance were observed in four groups: patients with only migraine (MGItem Four-Class Classification of Neuropsychiatric Disorders by Use of Functional Near-Infrared Spectroscopy Derived Biomarkers(MDPI, 2022-01-01) Erdogan, Sinem Burcu; Yukselen, GulnazDiagnosis of most neuropsychiatric disorders relies on subjective measures, which makes the reliability of final clinical decisions questionable. The aim of this study was to propose a machine learning-based classification approach for objective diagnosis of three disorders of neuropsychiatric or neurological origin with functional near-infrared spectroscopy (fNIRS) derived biomarkers. Thirteen healthy adolescents and sixty-seven patients who were clinically diagnosed with migraine, obsessive compulsive disorder, or schizophrenia performed a Stroop task, while prefrontal cortex hemodynamics were monitored with fNIRS. Hemodynamic and cognitive features were extracted for training three supervised learning algorithms (naive bayes (NB), linear discriminant analysis (LDA), and support vector machines (SVM)). The performance of each algorithm in correctly predicting the class of each participant across the four classes was tested with ten runs of a ten-fold cross-validation procedure. All algorithms achieved four-class classification performances with accuracies above 81\% and specificities above 94\%. SVM had the highest performance in terms of accuracy (85.1 +/- 1.77\%), sensitivity (84 +/- 1.7\%), specificity (95 +/- 0.5\%), precision (86 +/- 1.6\%), and F1-score (85 +/- 1.7\%). fNIRS-derived features have no subjective report bias when used for automated classification purposes. The presented methodology might have significant potential for assisting in the objective diagnosis of neuropsychiatric disorders associated with frontal lobe dysfunction.Item Diagnosis and Treatment in Vestibular Migraine(TURKISH NEUROLOGICAL SOC, 2020-01-01) Dikmen, Pinar YalinayVestibular migraine (VM) is the most common cause of recurrent spontaneous vertigo. Inclusion of the diagnostic criteria for VM in the last edition of the International Classification of Headache Disorders published in 2013 promoted the establishment of unity in terminology as well as increasing awareness about VM. The diagnosis of VM is based on clinical history. In studies related to VM, it has been shown that headache and vertigo may not always occur simultaneously, and vertigo may present in different patterns in individual attacks of patients. This variation creates difficulty in the diagnosis of VM. Therefore, the presence of headache should always be questioned in young and middle-aged patients who present with vertigo. Headache that was present previously may have disappeared years ago, hence a detailed patient history is the most essential tool in the diagnosis of VM. There may be some findings showing central and peripheral vestibular involvement in the neurotologic examination during ictal and interictal periods. However, there is no pathognomonic laboratory test