Araştırma Çıktıları

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    A Retrospective Multicenter Evaluation of Cutaneous Melanomas in Turkey
    (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2014-01-01) Gamsizkan, Mehmet; Yilmaz, Ismail; Buyukbabani, Nesimi; Demirkesen, Cuyan; Demiriz, Murat; Cetin, Emel Dikicioglu; Ince, Umit; Akalin, Taner; Demirkan, Nese Calli; Lebe, Banu; Erdem, Ozlem; Gokoz, Ozay; Sakiz, Damlanur; Demireli, Peyker Temiz; Astarci, Hesna Muzeyyen; Adim, Saduman Balaban; Zemheri, Itir Ebru; Acikalin, Arbil; Yaman, Banu; Aydin, Ovgu; Bassorgun, Cumhur Ibrahim
    Background: We defined melanoma distribution in a large series of Turkish patients and evaluated the prognostic parameters of melanomas. Materials and Methods: A total of 1574 patients' data was retrospectively collected at 18 centers in Turkey. Demographic characteristics were questioned and noted. Prognostic parametres were evaluated based on sentinel lymph node involvement. Results: Mean age was 56.7 (4-99) years. While 844 (53.6\%) cases were male, 730 (46.4\%) cases were female. One thousand four hundred forty-seven (92\%) cases were invasive melanoma and 127 (8\%) cases were in-situ melanoma. The most common histopathological form was the superficial spreading melanoma (SSM) which was found in 549 patients (37.9\%). It was followed by nodular melanoma in 379 (26.2\%), acral lentiginous melanoma (ALM) in 191 (13.2\%) and lentigo maligna melanoma in 132 (9.1\%), respectively. On univariate analysis, lymphovascular invasion (p<0.001), tumor thickness (p<0.001), histopathological subtype (p<0.001), Clark level (p=0.001), ulceration (p<0.001), >= 6/mm(2) mitosis (p=0.005), satellite formation (p=0.001) and gender (p=0.03) were found to be associated with sentinel lymph node positivity. Regression was associated with sentinel lymph node negativity (p=0.017). According to multivariate analysis, lymphovascular invasion and tumor thickness were significant independent predictive factors of SLN positivity. Patient age, tumor localization, precursor lesions, lymphocytic infiltration and neurotropism were not related with sentinel lymph node involvement. Conclusions: In this retrospective analysis, it was found that the prevalence of SSM is at a lower rate while the prevalence of ALM is at a higher rate when compared to western countries. According to Breslow index
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    The Effects of Dressing up Preterm Infants After Tub Bathing on Moisture Loss: A Randomized Controlled Trial
    (MARMARA UNIV, INST HEALTH SCIENCES, 2020-01-01) Onturk, Zehra Kan; Gozen, Duygu
    Objective: The skin of the preterm newborn plays an important role in adapting the newborn to the environment after birth. This was designed as a randomised controlled experimental trial in order to determine the effect of dressing after tub bathing on loss of skin moisture in healthy preterm infants. Methods: The population of the study consisted of the infants who were born between 33,0-36,6 weeks of gestation. Skin moisture (forehead, abdomen, back, arm, leg) and body temperature measurements of the infants before bathing, immediately after bathing, and 10, 20, 30, and 60th minutes after bathing were assessed. Results: It was determined that while the moisture was kept and increased in the experimental group, moisture loss occurred in the control group. The infants in both groups had heat loss after the bathing. Conclusion: It was determined that the skin moisture and body temperature of the experimental group infants were affected positively.