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    European Biological Variation Study (EuBIVAS): within- and between-subject biological variation estimates for serum thyroid biomarkers based on weekly samplings from 91 healthy participants
    (WALTER DE GRUYTER GMBH, 2022-01-01) Bottani, Michela; Aarsand, Aasne K.; Banfi, Giuseppe; Locatelli, Massimo; Coskun, Abdurrahman; Diaz-Garzon, Jorge; Fernandez-Calle, Pilar; Sandberg, Sverre; Ceriotti, Ferruccio; Carobene, Anna; Chem, European Federation Clinical
    Objectives Thyroid biomarkers are fundamental for the diagnosis of thyroid disorders and for the monitoring and treatment of patients with these diseases. The knowledge of biological variation (BV) is important to define analytical performance specifications (APS) and reference change values (RCV). The aim of this study was to deliver BV estimates for thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroglobulin (TG), and calcitonin (CT). Methods Analyses were performed on serum samples obtained from the European Biological Variation Study population (91 healthy individuals from six European laboratories
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    Thyroid status of female rhesus monkeys and preliminary information on impact of perchlorate administration
    (ROYAL SOC MEDICINE PRESS LTD, 2011-01-01) Ozpinar, Aysel; Golub, Mari S.; Poppenga, Robert H.; Blount, Benjamin C.; Gillespie, Jerry R.
    Thyroid status was assessed in adult female rhesus monkey breeders at the California National Primate Research Center at the beginning of the breeding season. The 95\% confidence intervals for thyrotropin (TSH), thyroxine (T(4)) and triiodothyronine (T(3)) (n = 66-80) were similar to those previously reported in smaller samples of macaque monkeys. Based on human criteria, 10 of 80 monkeys (12\%) were hypothyroid (TSH > 2.01 mu lU/mL). Because hypothyroxinaemia can be a risk factor in pregnancy, T(4) status was compared with past breeding history, breeding outcome for that season and general health records in a subset of 42 breeders. Age, weight and parity did not differ between monkeys in the lowest T(4) quartile as compared with those in the upper three quartiles. However, T(4) concentrations were significantly associated with the number of missed menstrual cycles during the previous breeding season. In additional work, three healthy lactating rhesus monkeys were given three different doses of environmental contaminant and thyroid iodine uptake inhibitor, ammonium perchlorate (0.006, 0.34, 12.8 mg/kg/day, respectively) in food for two weeks. Thyroid status variables (TSH, T(4), T(3), thyroid radioactive iodine uptake) were then measured. In the monkey receiving the highest perchlorate dose, iodine uptake was suppressed relative to baseline. The study shows the availability of tools to study thyroid status in rhesus monkeys, the variability of thyroid status in the breeder colony and the potential ability of environmental factors to influence thyroid status.
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    Subacute Thyroiditis and Graves' Disease Possibly Associated with Sars-CoV-2 Infection: Presentation of Two Cases and Review of the Current Data
    (AVES, 2022-01-01) Celik, Ozlem; Anaforoglu, Inan
    The severe acute respiratory syndrome coronavirus 2 has been identified as the cause of a pandemic of respiratory illness in Wuhan, China. Coronavirus disease 2019 may cause mild disease with nonspecific signs and symptoms such as fever, cough, myalgia, and fatigue or severe pneumonia with respiratory failure and sepsis. It is not clear whether coronavirus disease 2019 has an effect on the thyroid gland. Evidence support that patients with coronavirus disease 2019 who are followed up in the intensive care unit may develop temporary thyroid dysfunction as non-thyroidal illness syndrome. Until now, 22 cases of subacute thyroiditis and 5 Graves' diseases potentially related to severe acute respiratory syndrome coronavirus 2 infection have been presented in the literature. Herein, we present 2 cases with subacute thyroiditis and Graves'diseases potentially related to severe acute respiratory syndrome coronavirus 2 infection in the context of the review of the literature. Physicians should be aware of the possible relationship between thyroid dysfunction and coronavirus disease 2019.