Comparison of serum NEDD-9, CA 15-3, and CEA levels and PET metabolic parameters in breast cancer patients with 18 F-FDG PET/CT
Comparison of serum NEDD-9, CA 15-3, and CEA levels and PET metabolic parameters in breast cancer patients with 18 F-FDG PET/CT
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Tarih
2020-01-01
Yazarlar
Arslan, Esra
Aral, Hale
Aksoy, Tamer
Afsar, Cigdem Usul
Karabulut, Senem
Trabulus, Fadime Didem Can
Gursu, Riza Umar
Cermik, Tevfik Fikret
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
ASSOC MEDICA BRASILEIRA
Dergi Adı
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
Özet
OBJECTIVE: Analyze the over expression of neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) deregulated associated with a poor prognosis in various carcinomas. Our objective was to investigate the relationship between the levels of NEDD-9, CA 15-3, and CEA and PET (SUVmax, MTV40, TLG40) with the clinical parameters of patients with breast cancer (BC). METHODS: One hundred and eleven patients (82 BC patients who underwent 18F-FDG PET/CT and 29 healthy controls) were evaluated. SUVmax, MTV, and TLG of the primary tumor were compared with the molecular and histopathological subtypes. 18F-FDG, MTV, and TLG were evaluated based on the clinical data, i.e., nodal involvement, distant metastasis, ER and PR status, Ki-67, serum levels of NEDD-9, CA15-3, and CEA. We compared the NEDD-9 in the BC and healthy control groups. RESULTS: The mean +/- SD of SUVmax in the 82 patients was 13.0 +/- 8.6. A statistically significant relationship (p = 0.022) was found between the molecular subtypes and 18F-FDG uptake. The relationship between 18F-FDG uptake and TLG measured in patients <50 years, ER-PR negativity, and HER2 positivity were statistically significant (p=0.015, 0.007, 0.046, and 0.001, respectively). MTV40, TLG40, and CA 15-3 in metastatic patients were statistically significant (p=0.004, 0.005, and 0.003, respectively). NEDD-9 in the BC group was significantly higher than in the healthy group (p=0.017). There was a positive correlation between SUVmax and 1(167 and CA 15-3
MTV40 and CEA
CA 15-3, CEA, SUVmax, and MTV40
a negative correlation was found between CEA, TLG40, and age. CONCLUSION: The use of SUVmax, MTV40, and TLG40 parameters with NEDD-9 and tumor markers has been shown to provide a high diagnostic, predictive, and prognostic value for the management of BC. This is considered to be the basis of interventions focused on the treatment objectives related to NEDD-9.
MTV40 and CEA
CA 15-3, CEA, SUVmax, and MTV40
a negative correlation was found between CEA, TLG40, and age. CONCLUSION: The use of SUVmax, MTV40, and TLG40 parameters with NEDD-9 and tumor markers has been shown to provide a high diagnostic, predictive, and prognostic value for the management of BC. This is considered to be the basis of interventions focused on the treatment objectives related to NEDD-9.
Açıklama
Anahtar kelimeler
Breast neoplasms, Fluorodeoxyglucose F18, Adaptor proteins, signal-transducing, Carcinoembryonic antigen