Comparison of serum NEDD-9, CA 15-3, and CEA levels and PET metabolic parameters in breast cancer patients with 18 F-FDG PET/CT

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dc.contributor.authorArslan, Esra
dc.contributor.authorAral, Hale
dc.contributor.authorAksoy, Tamer
dc.contributor.authorAfsar, Cigdem Usul
dc.contributor.authorKarabulut, Senem
dc.contributor.authorTrabulus, Fadime Didem Can
dc.contributor.authorGursu, Riza Umar
dc.contributor.authorCermik, Tevfik Fikret
dc.date.accessioned2023-02-21T12:37:25Z
dc.date.available2023-02-21T12:37:25Z
dc.date.issued2020-01-01
dc.description.abstractOBJECTIVE: Analyze the over expression of neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) deregulated associated with a poor prognosis in various carcinomas. Our objective was to investigate the relationship between the levels of NEDD-9, CA 15-3, and CEA and PET (SUVmax, MTV40, TLG40) with the clinical parameters of patients with breast cancer (BC). METHODS: One hundred and eleven patients (82 BC patients who underwent 18F-FDG PET/CT and 29 healthy controls) were evaluated. SUVmax, MTV, and TLG of the primary tumor were compared with the molecular and histopathological subtypes. 18F-FDG, MTV, and TLG were evaluated based on the clinical data, i.e., nodal involvement, distant metastasis, ER and PR status, Ki-67, serum levels of NEDD-9, CA15-3, and CEA. We compared the NEDD-9 in the BC and healthy control groups. RESULTS: The mean +/- SD of SUVmax in the 82 patients was 13.0 +/- 8.6. A statistically significant relationship (p = 0.022) was found between the molecular subtypes and 18F-FDG uptake. The relationship between 18F-FDG uptake and TLG measured in patients <50 years, ER-PR negativity, and HER2 positivity were statistically significant (p=0.015, 0.007, 0.046, and 0.001, respectively). MTV40, TLG40, and CA 15-3 in metastatic patients were statistically significant (p=0.004, 0.005, and 0.003, respectively). NEDD-9 in the BC group was significantly higher than in the healthy group (p=0.017). There was a positive correlation between SUVmax and 1(167 and CA 15-3
dc.description.abstractMTV40 and CEA
dc.description.abstractCA 15-3, CEA, SUVmax, and MTV40
dc.description.abstracta negative correlation was found between CEA, TLG40, and age. CONCLUSION: The use of SUVmax, MTV40, and TLG40 parameters with NEDD-9 and tumor markers has been shown to provide a high diagnostic, predictive, and prognostic value for the management of BC. This is considered to be the basis of interventions focused on the treatment objectives related to NEDD-9.
dc.description.issue5
dc.description.issueMAY
dc.description.pages673-679
dc.description.volume66
dc.identifier.doi10.1590/1806-9282.66.5.673
dc.identifier.urihttps://hdl.handle.net/11443/2242
dc.identifier.urihttp://dx.doi.org/10.1590/1806-9282.66.5.673
dc.identifier.wosWOS:000546930300025
dc.publisherASSOC MEDICA BRASILEIRA
dc.relation.ispartofREVISTA DA ASSOCIACAO MEDICA BRASILEIRA
dc.subjectBreast neoplasms
dc.subjectFluorodeoxyglucose F18
dc.subjectAdaptor proteins, signal-transducing
dc.subjectCarcinoembryonic antigen
dc.titleComparison of serum NEDD-9, CA 15-3, and CEA levels and PET metabolic parameters in breast cancer patients with 18 F-FDG PET/CT
dc.typeArticle
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