Alterations of Neuroretinal and Corneal Thickness in Hashimoto’s Thyroiditis
Alterations of Neuroretinal and Corneal Thickness in Hashimoto’s Thyroiditis
Tarih
2022-01-01
Yazarlar
Olcaysü, Osman Okan
Karasu, Buğra
Olcaysü, Elif
Çayır, Atilla
Çelebi, Ali Rıza Cenk
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
Acıbadem Mehmet Ali Aydınlar Üniversitesi
Dergi Adı
Özet
ABSTRACT
Purpose:To compare changes in macula, retinal nerve fiber layer (RNFL) and central corneal thickness (CCT) in patients
with Hashimoto’s thyroiditis (HT) with age-matched healthy control group.
Materials and Methods: This study was conducted with a prospective, observational, cross-sectional design. The
individuals participating in the study were divided into 2 groups: patients with a diagnosis of HT (group 1, n:54 eyes)
and age-matched healthy participants (group 2, n:70 eyes). Corneal, retinal and macular thickness measured by optical
coherence tomography. Mean outcome measurements were CCT, intra-ocular pressure (IOP), central 1 mm foveal
thickness (CFT), subfoveal choroidal thickness (SFCT), total macular volume (TMV), central 1 mm foveal volume (CFV), and
RNFL thickness in superior, nasal, inferior and temporal quadrants.
Results:The mean IOP was 17.07±2.34μm in group 1 and 14.20±2.76μm in group 2, respectively (p<0.001). Mean CCTs
were 539.44±35.27μm and 555.06±40.53μm (p=0.001), CFTs were 227.35±17.52µm and 230.38±23.52µm (p=0.57),
SFCT were 210,79±20,13µm and 268,47±24,56µm (p<0.001), TMVs were 7.16±0.35mm3 and 7.02±0.26mm3(p=0.07),
CFVs were 0.17±0.01mm3 and 0.19±0.07mm3 (p=0.16) in group 1and group 2, respectively. RNFL thickness values were
significantly thinner in the group 1(p<0.05) in all quadrants except for the nasal quadrant (p=0.086).
Conclusion:Hypothyroidism secondary to HT may be a determining factor affecting the development of the cornea and
retina. Elevated IOP and decrement of RNFL thickness in children with HT increased the risk of developing glaucoma, as
well as decreased SFCT may predispose to the development of chorioretinal disorders in the future