Testis spectroscopy may predict sperm retrieval rate in men with non-obstructive azoospermia undergoing micro-TESE: A pilot study
Testis spectroscopy may predict sperm retrieval rate in men with non-obstructive azoospermia undergoing micro-TESE: A pilot study
Tarih
2020-01-01
Yazarlar
Celik, Onder
Hatirnaz, Safak
Ersahin, Aynur
Basbug, Alper
Yildirim, Gonca Yetkin
Ozener, Vahit
Gurpinar, Neslihan
Celik, Sudenaz
Celik, Nilufer
Kucuk, Tansu
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
GALENOS YAYINCILIK
Dergi Adı
JOURNAL OF THE TURKISH-GERMAN GYNECOLOGICAL ASSOCIATION
Özet
Objective: To investigate whether prior testis magnetic resonance spectroscopy predicts the success or failure of micro-dissection testicular sperm extraction (micro-TESE) in patients with non-obstructive azoospermia (NOA). Material and Methods: Nine men with NOA who were scheduled for micro-TESE for the first time, 9 NOA men with a history of previous micro-TESE and 5 fertile men were enrolled. All NOA patients and fertile controls underwent testis spectroscopy. A multi-voxel spectroscopy sequence was used. Testicular signals of choline (Cho), creatine (Cr), myo-inositol (MI), lactate, and lipids were analyzed quantitatively and compared with the results of the micro-TESEs. Results: The most prominent peaks were Cho and Cr in the fertile controls and NOA subjects with positive sperm retrieval in the micro-TESE. A high Cho peak was detected in 87\% of the NOA men with positive sperm retrieval. NOA men without sperm at the previous micro-TESE showed a marked decrease in Cho and Cr signals. For positive sperm retrieval in micro-TESE, the cut-off value of Cho was 1.46 ppm, the cut-off value of Cr was 1.43 ppm, and the cut-off value of MI was 0.79 ppm. Conclusion: Testis spectroscopy can be used as a non-invasive screening method to predict the success or failure of micro-TESE.
Açıklama
Anahtar kelimeler
Testis, magnetic resonance spectroscopy, sperm retrieval, micro-TESE, non-obstructive azoospermia