An Evaluation of Chronic Hepatitis C Patients' Responses to Direct-Acting Antivirals According to Transient Elastography and Serum Biomarkers

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dc.contributor.authorAydin, Nurten Nur
dc.contributor.authorKoksal, Iftihar
dc.date.accessioned2023-02-21T12:33:12Z
dc.date.available2023-02-21T12:33:12Z
dc.date.issued2022-01-01
dc.description.abstractObjectives: In this study, it was evaluated the changes in liver stiffness measurements measured by AST to Platelet Ratio index (APRI), Fibrosis 4 index (FIB-4), Age Platelet index (API), AST-ALT ratio (AAR) and transient elastography (TE) among the non-invasive fibrosis scores in chronic hepatitis C (CHC) patients treated with direct-acting agents (DM) and the effect of treatment. Materials and Methods: Ombitasvir-paritaprevir-ritonavir-dasabuvir +/- ribavirin (RBV) or sofosbuvir +/- ledipasvir (SOF +/- LDV) +/- RBV was given to the patients. Fibrosis scores were calculated with the biochemical data of the patients before the treatment, at the 4s . week of the treatment, at the end of treatment and at the sustained virological response 12 (SVR12) Liver stiffness measurements were recorded before treatment with TE and in SVR12. Post-treatment SVR12 responses were evaluated. Results: SVR12 was achieved in 97.9\% of 95 patients included in the study. Significant regression was found in APRI and FIB-4 scores, which are among the 4 serum fibrosis markers calculated in all patients (p<0.001, p<0.001). Liver stiffness was measured using TE in 75 patients. It was determined that the liver stiffness measurement (9.3 +/- 6.5 kPa) in SVR12 significantly decreased compared to the baseline (11.6 +/- 7.8 kPa) (p<0.001). Conclusion: DAA provides improvement in fibrosis scores and persistent viral response in patients. In our study, in which fibrosis was evaluated non-invasive methods, it was observed that there was a significant improvement in liver fibrosis with APRI, FIB-4 and TE measurements.
dc.description.issue1
dc.description.issueAPR
dc.description.pages18-24
dc.description.volume28
dc.identifier.doi10.4274/vhd.galenos.2022.2021-8-2
dc.identifier.urihttps://hdl.handle.net/11443/1417
dc.identifier.urihttp://dx.doi.org/10.4274/vhd.galenos.2022.2021-8-2
dc.identifier.wosWOS:000791036500004
dc.publisherGALENOS YAYINCILIK
dc.relation.ispartofVIRAL HEPATIT DERGISI-VIRAL HEPATITIS JOURNAL
dc.subjectHepatitis C
dc.subjectdirect-acting antivirals
dc.subjectliver fibrosis
dc.subjecttransient elastography
dc.subjectAPRI
dc.subjectFIB-4
dc.titleAn Evaluation of Chronic Hepatitis C Patients' Responses to Direct-Acting Antivirals According to Transient Elastography and Serum Biomarkers
dc.typeArticle
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