The Relationship between the Sydney Classification and the First-Line Treatment Efficacy in Helicobacter-Associated Gastritis
dc.contributor.author | Tasci, Elif Senocak | |
dc.contributor.author | Akbas, Turkay | |
dc.date.accessioned | 2023-02-21T12:32:41Z | |
dc.date.available | 2023-02-21T12:32:41Z | |
dc.date.issued | 2020-01-01 | |
dc.description.abstract | Objective: Helicobacter pyloriis responsible for a wide spectrum of diseases. Due to ease of use and access, the standard triple therapy is being used as first-line eradication in many areas. Intestinal metaplasia (IM) is a precancerous lesion that requires eradication therapy. Our aim is to investigate the effect of IM on the standard triple therapy success in H. pylori-positive patients. Subjects and Methods: The patients who were referred to Duzce University Hospital and Avrasya Hospital Gastroenterohepatology clinic between January 2014 and December 2016 and diagnosed with H. pylori-positive gastritis and underwent first-line eradication were evaluated retrospectively. Biopsy specimens were evaluated according to the updated Sydney system. All patients diagnosed with H. pylori started treatment with pantoprazole 40 mg b.i.d., amoxicillin 1 g b.i.d. and clarithromycin 500 mg b.i.d. for 14 days. Results: The mean age of 181 patients included in the study was 55.5 +/- 7.8. The success rate of H. pylori eradication was found to be low in severe chronic inflammation (p = 0.001). The success rate was found to be high among patients with no neutrophil activity (p = 0.009). As the intensity of IM increased, density of H. pylori was found to be decreased (p = 0.019). There was no correlation between glandular atrophy, IM, and H. pylori eradication success rate (p = 0.390 and p = 0.812). Conclusion: The severity of chronic inflammation is the most effective Sydney criteria for success of eradication, while the presence on IM does not have any effect. | |
dc.description.issue | 6 | |
dc.description.issue | DEC | |
dc.description.pages | 551-557 | |
dc.description.volume | 29 | |
dc.identifier.doi | 10.1159/000508248 | |
dc.identifier.uri | https://hdl.handle.net/11443/1214 | |
dc.identifier.uri | http://dx.doi.org/10.1159/000508248 | |
dc.identifier.wos | WOS:000598144300007 | |
dc.publisher | KARGER | |
dc.relation.ispartof | MEDICAL PRINCIPLES AND PRACTICE | |
dc.subject | Eradication | |
dc.subject | Gastritis | |
dc.subject | Helicobacter pylori | |
dc.subject | Intestinal metaplasia | |
dc.subject | Sydney classification | |
dc.title | The Relationship between the Sydney Classification and the First-Line Treatment Efficacy in Helicobacter-Associated Gastritis | |
dc.type | Article |
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