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Item Association between renin-angiotensin-aldosterone system inhibitor treatment, neutrophil-lymphocyte ratio, D-Dimer and clinical severity of COVID-19 in hospitalized patients: a multicenter, observational study(SPRINGERNATURE, 2021-01-01) Gormez, Selcuk; Ekicibasi, Erkan; Degirmencioglu, Aleks; Paudel, Ashok; Erdim, Refik; Gumusel, Hilal Kurtoglu; Eroglu, Elif; Tanboga, Ibrahim Halil; Dagdelen, Sinan; Sariguzel, Nevin; Kirisoglu, Ceyda Erel; Pamukcu, BurakThe aim of this study was to investigate the possible relationship between worse clinical outcomes and the use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) in hospitalized COVID-19 patients. A total of 247 adult patients (154 males, 93 femalesItem Association between serum vitamin D levels and subclinical coronary atherosclerosis and plaque burden/composition in young adult population(ASSOC BASIC MEDICAL SCI FEDERATION BOSNIA \& HERZEGOVINA SARAJEVO, 2015-01-01) Satilmis, Seckin; Celik, Omer; Biyik, Ismail; Ozturk, Derya; Celik, Kubra Asik; Akin, Fatih; Ayca, Burak; Yalcin, Burce; Dagdelen, SinanEvidence suggests that low 25-OH vitamin D (25)(OH)D concentrations may increase the risk of several cardiovascular diseases such as hypertension, peripheral vascular disease, diabetes mellitus, obesity, myocardial infarction, heart failure and cardiovascular mortality. Recent studies suggested a possible relationship between vitamin I) deficiency and increased carotid intima-media wall thickness and vascular calcification. We hypothesized that low 25(OH)D may be associated with coronary atherosclerosis and coronary plaque burden and composition, and investigated the relationship between serum vitamin I) levels and coronary atherosclerosis, plaque burden or structure, in young adult patients by using dual-source 128x2 slice coronary computed tomography angiography (CCTA). We included 98 patients with coronary atherosclerosis and 110, age and gender matched, subjects with normal findings on CCTA examinations. Patients with subclinical atherosclerosis had significantly higher serum total cholesterol, triglycerides, hs-CRP, uric acid, HbA1c and creatinine levels and lower serum 25(OH)l) levels in comparison with controls. There was no significant correlation between 25(OH)D and plaque morphology. There was also a positive relationship between 25(OH)D and plaque burden of coronary atherosclerosis. In multivariate analysis, coronary atherosclerosis was associated high hs-CRP (adjusted OR: 2.832), uric acid (adjusted OR: 3.671) and low 25(OH)D (adjusted OR: 0.689). Low levels of 25(OH)D were associated with coronary atherosclerosis and plaque burden, but there was no significant correlation between 25(OH)D and plaque morphology.Item The long-term incidence and predictors of radial artery occlusion following a transradial coronary procedure(VIA MEDICA, 2014-01-01) Buturak, Ali; Gorgulu, Sevket; Norgaz, Tugrul; Voyvoda, Nuray; Sahingoz, Yusuf; Degirmencioglu, Aleks; Dagdelen, SinanBackground: Radial artery occlusion (RAO) is an infrequent complication of transradial coronary procedures (TRA). To our knowledge, there is no satisfactory data regarding the late term incidence and predictors of RAO in the literature. Our aim was to establish the long-term incidence of radial artery occlusion and investigate its predictors. Methods: This was a single center prospective study. A total number of 409 consecutive patients undergoing their first TRA were recruited. Clinical and procedural data were all recorded. Doppler ultrasound examination was performed at 6-15 months following the intervention. Results: RAO was detected in 67 patients and 342 patients maintained radial artery patency. The overall RAO incidence was 16.4\% at late term. Patients with RAO were younger than the patients with patent radial arteries (55.9 +/- 9.7 vs. 59.1 +/- 9.4 years, p = 0.014). The incidence of RAO in hypertensive patients (9.8\%) was lower (p < 0.001) than the observed incidence (23\%) in non-hypertensive patients. RAO group had higher rate (28\%, p = 0.027) of post-procedural access site pain. Regression analysis revealed that hypertension was negative while post-procedural access site pain was positive independent predictors for RAO. In addition, the relative risk for RAO also increased significantly (p < 0.001) when the ratio of sheath/artery diameter (S/A) was > 1. Conclusions: The present study reveals that the long-term incidence of RAO is 16.4\%. Hypertension, post-procedural access site pain and S/A ratio > 1 are independent predictors of RAO at late term.Item Transcatheter aortic valve implantation in a patient with bicuspid aortic stenosis and a borderline-sized annulus(OXFORD UNIV PRESS, 2015-01-01) Colkesen, Yucel; Baykan, Oytun; Dagdelen, Sinan; Cayli, MuratBicuspid aortic valve (BAV) is currently considered an exclusion criterion for transcatheter aortic valve implantation (TAVI). The risk of adverse aortic events such as incomplete sealing, severe paravalvular regurgitation or dislocation due to elliptic shape and asymmetric calcifications in annulus are higher in TAVI. In this case report, we detailed a case of successful trans-femoral TAVI in a 51-year old male with BAV and its management without in-hospital and 30-day complications. The challenge in this case was the patient's anatomy with a 27-mm annulus for balloon expandable device. The applied strategy was balloon sizing and overdilating the 29-mm stented valve with additional volume that obviated re-ballooning. Trans-femoral TAVI was performed uneventfully under fluoroscopic and transoesophageal echocardiography guidance. A multidetector computed tomography (MDCT) evaluation at 1 month did not show device dislodgement or any other complications. Evidence for evaluation post-TAVI is not sufficient in BAV. We believe patients with BAV should undergo a comprehensive assessment after TAVI including MDCT evaluation.Item A hybrid therapy as a third approach for type 1 proximal endoleak of thoracic endovascular aortic replacement: Caroticocarotid bypass and re-redo endovascular therapy(ELSEVIER SCIENCE BV, 2013-01-01) Ariturk, Cem; Okten, Murat; Dagdelen, Sinan; Toraman, Fevzi; Karabulut, HasanIntroduction: In selected cases with thoracic aortic aneurysm (TAA), thoracic endovascular aortic replacement (TEVAR) is commonly used and shall be proper therapy method. We are presenting a case of TAA previously treated twice by endovascular aortic approaches and complicated by type 1 endoleak. Case: A 67-year-old male patient was admitted to our clinic with back pain at rest. He underwent TEVAR five years ago, twice in 6 month. With contrasted computed tomography of chest and abdomen, a new type 1 proximal endoleak was diagnosed, and after routine preoperative follow up, the patient was operated on. At the same session right to left caroticocarotid bypass and re-redo TEVAR were performed. The new endovascular graft was placed as the proximal landing zone to be set between left carotid artery and brachiocephalic truncus. The patient was discharged on postoperative day 4 without any problems. Conclusion: As new techniques and methods have been developed, mortality rates have decreased to 2-3\% but in older and high risk patients, mortality rates still remain high {[}1]. TEVAR is a safe and effective treatment method in the proper and selected patients with thoracic artery aneurysm {[}2]. Moreover, TEVAR can also be performed as a part of hybrid procedures for arcus aortic aneurysms {[}3]. But it should be kept in mind that late secondary intervention rates are higher in TEVAR. (C) 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.Item The Long Term Incidence and Predictors of Radial Artery Occlusion Following a Transradial Coronary Procedure(2013-01-01) Buturak, Ali; Gorgulu, Sevket; Norgaz, Tugrul; Voyvoda, Nuray; Sahingoz, Yusuf; Degirmencioglu, Alex; Demirci, Yasemin; Dagdelen, SinanItem Transcatheter aortic valve implantation applications in Turkey(TURKISH SOC CARDIOLOGY, 2012-01-01) Dagdelen, Sinan; Alhan, CemItem Late Myocardial Ischemia Induced by a Large Fistula Between Left Internal Mammary Graft and Left Pulmonary Vein System(GALENOS PUBL HOUSE, 2012-01-01) Dagdelen, Sinan; Norgaz, Tugrul; Gorgulu, SevketItem Interventional therapy in resistant hypertension(TURKISH SOC CARDIOLOGY, 2012-01-01) Dagdelen, Sinan; Batur, Mustafa KemalItem Simultaneous endovascular stent and renal stent placement for acute type B aortic dissection with malperfusion of kidney(ELSEVIER SCIENCE BV, 2012-01-01) Dagdelen, Sinan; Aydin, Ebuzer; Karabulut, HasanAcute aortic dissection frequently causes life-threatening organ ischemia. The optimal therapy for acute type-B aortic dissection is still controversial. Surgery for acute dissection with organ malperfusion is known to carry a high morbidity and mortality