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    Protective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats
    (IJO PRESS, 2017-01-01) Tugcu, Betul; Nacaroglu, Senay Asik; Gedikbasi, Asuman; Uhri, Mehmet; Acar, Nur; Ozdemir, Hakan
    AIM: To investigate the effect of pomegranate juice (PJ) intake on overall oxidation status in retinas of diabetic rats. METHODS: Twenty-seven rats were divided into four groups as control (CO), diabetic (DM), control treated with PJ (CO-PJ), and diabetic treated with PJ (DM-PJ). The retina tissues were used to determine 8-hydroxy2 `-deoxyguanosine (8OHdG), malondialdehyde (MDA), reduced glutathione (GSH) levels, and the enzyme activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). RESULTS: The levels of 8OHdG and MDA were significantly increased in the retina of DM group compared to CO group (P= 0.001, P< 0.001 respectively). Both 8OHdG and MDA levels were decreased in PJ-DM group compared to DM group (P= 0.004, P< 0.001 respectively). The activities of antioxidant enzymes GSH, SOD, and GDH-Px were significantly decreased in the retina of DM group compared to CO group (P= 0.01). GSH and GSH-Px activities were higher in PJ-DM group compared with DM group (P= 0.010, P= 0.042, respectively) but SOD activity was not statistically different (P= 0.938). CONCLUSION: PJ intake is found to be effective in decreasing oxidative end products, and in increasing the activities of antioxidant enzymes in diabetic retinas of rats, which suggests it may be effective against oxidative stress in diabetic retinas.
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    Morphological evaluation of the effects of exercise on high-fat-diet-induced liver damage in rats
    (AVES, 2020-01-01) Elmas, Merve Acikel; Atay, Nilsu; Ozakpinar, Ozlem Bingol; Arbak, Serap; Kolgazi, Meltem; Sener, Goksel; Ercan, Feriha
    Background/Aims: This study was aimed to investigate the protective effects of swimming on nonalcoholic fatty liver disease associated with high-fat-diet-induced obesity using microscopic and biochemical parameters. Materials and Methods: Sprague-Dawley male rats were fed either standard chow (STD group
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    The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress, and advanced glycation end products in experimental nonalcoholic- and alcoholic- fatty liver disease
    (SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, 2021-01-01) Bingul, Ilknur; Aydin, A. Fatih; Kucukgergin, Canan; Dogan-Ekici, Isin; Dogru-Abbasoglu, Semra; Uysal, Mujdat
    Background/aim: Oxidative stress and advanced glycation end products (AGEs) formation are proposed as effective mechanisms in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). 1,25(OH)(2)D-3 was proposed to have antioxidant, antiinflammatory and antiglycation properties. In this study, the effect of 1,25(OH)(2)D-3 treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats. Materials and methods: Rats were treated with fructose (30\%) or ethanol (5-20\%) in drinking water with and without 1,25(OH)(2)D-3 treatment (5 mu g/kg two times a week) for 8 weeks. Insulin resistance (IR), oxidative stress parameters, AGEs, triglyceride (TG), and hydroxyproline (Hyp) levels together with histopathology were investigated in the liver. Results: 1,25(OH)(2)D-3 decreased hepatic reactive oxygen species, lipid and protein oxidation products together with histopathological improvements in HFr- and EtOH-treated rats. 1,25(OH)(2)D-3 treatment was observed to decrease significantly serum and hepatic AGEs in HFr group, and hepatic AGEs in EtOH group. Conclusion: Our results clearly show that 1,25(OH)(2)D-3 treatment may be useful in the alleviation of hepatic lesions by decreasing glycooxidant stress in both NAFLD and ALD models created by HFr- and EtOH-treated rats, respectively.