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    The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
    (WILEY, 2022-01-01) Adamina, Michel; Ademuyiwa, Adesoji; Adisa, Adewale; Bhangu, Aneel A.; Bravo, Ana Minaya; Cunha, Miguel F.; Emile, Sameh; Ghosh, Dhruva; Glasbey, James C.; Harris, Benjamin; Keller, Debby; Lawday, Samuel; Lederhuber, Hans; Leventoglu, Sezai; Li, Elizabeth; Modolo, Maria Marta; Mittal, Rohin; Mohan, Helen M.; Nepogodiev, Dmitri; Parreno-Sacdalan, Marie Dione; Pata, Francesco; Pockney, Peter; Rutegard, Martin; Simoes, Joana F. F.; Smart, Neil; Varghese, Chris; Siaw-Acheampong, Kwabena; Benson, Ruth A.; Bywater, Edward; Chaudhry, Daoud; Dawson, Brett E.; Evans, Jonathan P.; Gujjuri, Rohan R.; Heritage, Emily; Jones, Conor S.; Kamarajah, Sivesh K.; Khatri, Chetan; Khaw, Rachel A.; Keatley, James M.; Knight, Andrew; Smart, Neil J.; Minaya-Bravo, Ana; Gallo, Gaetano; Moug, Susan; Di Saverio, Salomone; Vallance, Abigail; Vimalchandra, Dale; Griffiths, Ewen A.; Evans, Richard P. T.; Townen, Philip; Roberts, Keith; McKay, Siobhan; Isaac, John; Satoi, Sohei; Edwards, John; Coonar, Aman S.; Marchbank, Adrian; Caruana, Edward J.; Layton, Georgia R.; Patel, Akshay; Brunelli, Alessandro; Ford, Samuel; Desai, Anant; Gronchi, Alessandro; Fiore, Marco; Almond, Max; Tirotta, Fabio; Dumitra, Sinziana; Kolias, Angelos; Price, Stephen J.; Fountain, Daniel M.; Jenkinson, Michael D.; Hutchinson, Peter; Marcus, Hani J.; Piper, Rory J.; Lippa, Laura; Servadei, Franco; Esene, Ignatius; Freyschlag, Christian; Neville, Iuri; Rosseau, Gail; Schaller, Karl; Demetriades, Andreas K.; Robertson, Faith; Alamri, Alex; Shaw, Richard; Schache, Andrew G.; Winter, Stuart C.; Ho, Michael; Nankivell, Paul; Biel, Juan Rey; Batstone, Martin; Ganly, Ian; Vidya, Raghavan; Wilkins, Alex; Singh, Jagdeep K.; Thekinkattil, Dinesh; Sundar, Sudha; Fotopoulou, Christina; Leung, Elaine Yl; Khan, Tabassum; Chiva, Luis; Sehouli, Jalid; Fagotti, Anna; Cohen, Paul; Gutelkin, Murat; Ghebre, Rahel; Konney, Thomas; Pareja, Rene; Bristow, Rob; Dowdy, Sean; Shylasree, T. S.; Seenivasagam, Rajkumar Kottayasamy; Ng, Joe; Fujiwar, Keiichi; Stewart, Grant D.; Lamb, Benjamin; Narahari, Krishna; McNeill, Alan; Colquhoun, Alexandra; McGrath, John S.; Bromage, Steve; Barod, Ravi; Kasivisvanathan, Veeru; Klatte, Tobias; Abbott, Tom E. F.; Abukhalaf, Sadi; Ademuyiwa, Adesoji O.; Agarwal, Arnav; Akkulak, Murat; Alameer, Ehab; Alderson, Derek; Alakaloko, Felix; Albertsmeier, Markus; Alser, Osaid; Alshaar, Muhammad; Alshryda, Sattar; Arnaud, Alexis P.; Augestad, Knut Magne; Ayasra, Faris; Azevedo, Jose; Bankhead-Kendall, Brittany K.; Barlow, Emma; Beard, David; Blanco-Colino, Ruth; Brar, Amanpreet; Breen, Kerry A.; Bretherton, Chris; Buarque, Igor Lima; Burke, Joshua; Chaar, Mohammad; Chakrabortee, Sohini; Christensen, Peter; Cox, Daniel; Cukier, Moises; Davidson, Giana H.; Drake, Thomas M.; Edwards, John G.; Elhadi, Muhammed; Farik, Shebani; Fitzgerald, J. Edward; Garmanova, Tatiana; Gomes, Gustavo Mendonca Ataide; Grecinos, Gustavo; Gruendl, Magdalena; Halkias, Constantine; Harrison, Ewen M.; Hisham, Intisar; Hutchinson, Peter J.; Hwang, Shelley; Isik, Arda; Jonker, Pascal; Kaafarani, Haytham M. A.; Kruijff, Schelto; Lawani, Ismail; Litvin, Andrey; Loehrer, Andrew; Loffler, Markus W.; Lorena, Maria Aguilera; Major, Piotr; Martin, Janet; Mashbari, Hassan N.; Mazingi, Dennis; Metallidis, Symeon; Moore, Rachel; Moszkowicz, David; Ng-Kamstra, Joshua S.; Maimbo, Mayaba; Negoi, Ionut; Niquen, Milagros; Ntirenganya, Faustin; Olivos, Maricarmen; Oussama, Kacimi; Outani, Oumaima; Rivera, Carlos Jose Perez; Pinkney, Thomas D.; van der Plas, Willemijn; Qureshi, Ahmad; Radenkovic, Dejan; Ramos-De La Medina, Antonio; Richards, Toby; Roslani, April C.; Segura-Sampedro, Juan Jose; Santos, Irene; Sayyed, Raza; Schache, Andrew; Schnitzbauer, Andreas A.; Seyi-Olajide, Justina O.; Sharma, Neil; Shaw, Catherine A.; Shu, Sebastian; Soreide, Kjetil; Spinelli, Antonino; Sund, Malin; Tabiri, Stephen; Townend, Philip; Tsoulfas, Georgios; van Ramshorst, Gabrielle H.; Vimalachandran, Dale; Warren, Oliver J.; Wedderburn, Duane; Wrigh, Naomi; Valenzuela I, J.; Alurralde, C.; Caram, E. L.; Eskinazi, D. G.; Badra, R.; Garcia, J. S.; Lucchini, S. M.; Vasey, C.; Watson, E.; Cecire, J.; Salindera, S.; Sutherland, A.; Ahn, J. H.; Chen, S.; Gauri, N.; Jang, S.; Jia, F.; Mulligan, C. S.; Yang, W.; Ye, G.; Zhang, H.; Moss, J.; Richards, T.; Thian, A.; Vo, U. G.; Bagraith, K.; Chan, E.; Ho, D.; Jeyarajan, E.; Jordan, S.; Nolan, G. J.; Von Papen, M.; Wullschleger, M.; Dawson, A. C.; Drane, A.; Egoroff, N.; Gani, J.; Lott, N.; Pockney, P.; Phan, D.; Townend, D.; Bong, C.; Gundara, J.; Bowman, S.; Guerra, G. R.; Gerns, N.; Riddell, A.; Dudi-Venkata, N. N.; Kroon, H. M.; Sammour, T.; Mitchell, D.; Swinson, B.; Waldron, A.; Walker, P.; Lun, E. W. Y.; Messner, F.; Ofner, D.; Emmanuel, K.; Grechenig, M.; Gruber, R.; Harald, M.; Jager, T.; Ohlberger, L.; Presl, J.; Wimmer, A.; Samadov, E.; Barker, D.; Boyce, R.; Doyle, A.; Eastmond, A.; Gill, R.; O'Shea, M.; Padmore, G.; Paquette, N.; Phillips, E.; St John, S.; Walkes, K.; Flamey, N.; Pattyn, P.; Ceelen, W.; Van de Putte, D.; Van Nieuwenhove, Y.; Van Ramshorst, G.; Willaert, W.; Oosterlinck, W.; Van den Eynde, J.; Van den Eynde, R.; Aguiar Jr., Junior S.; Marques, T.; Camara, P.; De Lima, R. K.; Della Giustina, E.; Hoffmann V, P.; Nacif, L.; Ferro, Carvalho C.; Gomes, G. M. A.; Buarque I, Lima; Leite, Lira dos Santos A.; Pol-Fachin, L.; Bezerra, Santos T.; Silva, A.; Silvestre, D.; Barros, Vieira A.; Laporte, G.; Salem, M.; Awada, Barakat J.; Ijichi, T. R.; Kim, N. J.; Marreiro, A.; Muller, B.; Nunes, R.; Bodanese, B.; Isoton, J. C.; de Sampaio, Regina L.; Vendrame, C.; Sokolov, M.; Gribnev, P.; Boutros, M.; Caminsky, N.; Ghitulescu, G.; Groot, G.; Persad, A.; Pham, H.; Wood, M.; Demyttenaere, S.; Garfinkle, R.; Brown, C.; Karimuddin, A.; Lee, N.; Liu, J.; Kia, Madani T.; Phang, P. T.; Raval, M.; Tom, K.; Martel, A.; Nessim, C.; Stevenson, J.; Al Riyami, S.; Bali, K.; Bigam, D.; Dajani, K.; Dell, A.; Bellolio, F.; Besser, N.; Grasset, E.; Inzunza, M.; Martinic, Quintana M.; Altamirano, Riquoir C.; Esquide, Ruiz M.; Arias-Amezquita, F.; Cetares, C.; Murgueitio, Cortes N.; Gomez-Mayorga, J. L.; Abadia, M.; Bonilla, A.; Facundo, H.; Guevara, O.; Mora, Herrera D. R.; Ramirez, Jimenez L. J.; Manrique, E.; Morales, Pinilla R. E.; Ferro, Rey M.; Cuasquen, Velasquez B. G.; Karlovic, D.; Krsul, D.; Zelic, M.; Dijan, E.; Katusic, Z.; Mihanovic, J.; Rakvin, I.; Almezghwi, H.; Arslan, K.; Ozant, A.; Ozcay, N.; Frantzeskou, K.; Gouvas, N.; Kokkinos, G.; Papatheodorou, P.; Pozotou, I.; Stavrinidou, O.; Yiallourou, A.; Martinek, L.; Skrovina, M.; Szubota, I.; Peteja, M.; Zatecky, J.; Avlund, T.; Christensen, P.; Harbjerg, J. L.; Iversen, L. H.; Kjaer, D. W.; Kristensen, H. O.; Mekhael, M.; Ebbehoj, A. L.; Krarup, P.; Schlesinger, N.; Smith, H.; Crespo, A.; Diaz, P.; Rivas, R.; Tactuk, N.; El Kassas, M.; Omar, W.; Tawheed, A.; Talaat, M.; Abdelsamed, A.; Azzam, A. Y.; Salem, H.; Seleim, A.; Al Sayed, M.; Ashoush, F.; Elazzazy, E.; Essam, E.; Ewedah, M.; Hassan, E.; Metwalli, M.; Mourad, M.; Qatora, M. S.; Sabry, A.; Samih, A.; Abdelaal, Samir A.; Shehata, S.; Shenit, K.; Attia, D.; Kamal, N.; Osman, N.; Alaa, S.; Hamza, H. M.; Elghazaly, M. S.; Mohammed, M. M.; Nageh, M. A.; Saad, M. M.; Yousof, E. A.; Eldaly, A.; Alrahawy, M.; Sakr, A.; Soliman, H.; Soltan, H.; Amira, G.; Sallam, I.; Sherief, M.; Sherif, A.; Ghaly, G.; Hamdy, R.; Morsi, A.; Sherif, G.; Abdeldayem, H.; Salama I, Abdelkader; Balabel, M.; Fayed, Y.; Sherif, Ahmed Elshawadfy; Elmorsi, R.; Refky, B.; Bekele, K.; Kauppila, J. H.; Sarjanoja, E.; Helminen, O.; Huhta, H.; Beyrne, C.; Jouffret, L.; Marie-Macron, L.; Fredon, F.; Roux, A.; Lakkis, Z.; Manfredelli, S.; Chebaro, A.; El Amrani, M.; Lecolle, K.; Piessen, G.; Eveno, C.; Noiret, B.; Pruvot, Veziant J.; Zerbib, P.; Ballouhey, Q.; Barrat, B.; Taibi, A.; Bergeat, D.; Merdrignac, A.; Le Roy, B.; Perotto, L. O.; Scalabre, A.; Aime, A.; Ezanno, A. C.; Malgras, B.; Bouche, P. A.; Tzedakis, S.; Cotte, E.; Glehen, O.; Bendjemar, L.; Braham, H.; Charre, L.; El Arbi, N.; Police, A.; Volpin, E.; D'Urso, A.; Mutter, D.; Seeliger, B.; Bonnet, S.; Denet, C.; Fuks, D.; Laforest, A.; Pourcher, G.; Seguin-givelet, A.; Tribillon, E.; Duchalais, E.; Bork, U.; Fritzmann, J.; Praetorius, C.; Weitz, J.; Welsch, T.; Beyer, K.; Kamphues, C.; Lauscher, J.; Loch, F. N.; Schineis, C.; Albertsmeier, M.; Kappenberger, A.; Schiergens, T.; Werner, J.; Becker, R.; Jonescheit, J.; Pergolini, I.; Reim, D.; Herzberg, J.; Honarpisheh, H.; Strate, T.; Boeker, C.; Hakami, I.; Jw, Mall; Nowak, K.; Reinhard, T.; Kleeff, J.; Michalski, C.; Ronellenfitsch, U.; Bertolani, E.; Konigsrainer, A.; Loffler, M. W.; Quante, M.; Steidle, C.; Yurttas, C.; Izbicki, J.; Nitschke, C.; Perez, D.; Uzunoglu, F. G.; Antonakis, P.; Contis, I.; Dellaportas, D.; Gklavas, A.; Konstadoulakis, M.; Memos, N.; Papaconstantinou, I.; Polydorou, A.; Theodosopoulos, T.; Vezakis, A.; Antonopoulou I, M.; Manatakis, D. K.; Tasis, N.; Arkadopoulos, N.; Danias, N.; Economopoulou, P.; Frountzas, M.; Kokoropoulos, P.; Larentzakis, A.; Michalopoulos, N.; Parasyris, S.; Selmani, J.; Sidiropoulos, T.; Vassiliu, P.; Bouchagier, K.; Klimopoulos, S.; Paspaliari, D.; Stylianidis, G.; Akrivou, D.; Baxevanidou, K.; Bouliaris, K.; Chatzikomnitsa, P.; Delinasios, G.; Doudakmanis, C.; Efthimiou, M.; Giaglaras, A.; Kalfountzos, C.; Kolla, C.; Koukoulis, G.; Zervas, K.; Zourntou, S.; Baloyiannis, I.; Diamantis, A.; Perivoliotis, K.; Tzovaras, G.; Christidis, P.; Ioannidis, O.; Loutzidou, L.; Karaitianos, I. G.; Geroukalis, A.; Baili, E.; Charalabopoulos, A.; Liakakos, T.; Schizas, D.; Spartalis, E.; Syllaios, A.; Zografos, C.; Christou, C.; Papadopoulos, V.; Tooulias, A.; Tsoulfas, G.; Athanasakis, E.; Chrysos, E.; Tsiaoussis, I.; Xenaki, S.; Xynos, E.; Futaba, K.; Ho, M. F.; Hon, S.; Mak, T. W. C.; Ng, S.; Foo, C. C.; Banky, B.; Susztak, N.; Misra, S.; Pareek, P.; Vishnoi, J. R.; Jain, A.; Mishra, S.; Mishra, T.; Mitra, J. K.; Muduly, D.; Agrawal, A.; Garg, P. K.; Seenivasagam, Kottayasamy R.; Majumdar, K. S.; Mishra, N.; Singh, M. P.; Patnaik, Chyau S.; Rao, S.; Reddy, P.; Saksena, A. R.; Seshadri, Ayloor R.; Haque, P. D.; Jeyaraj, P.; Veetil, Kannummal S.; Mahajan, A.; Devarakonda, S.; Jesudason, M. R.; Mittal, R.; Moorthy, M.; Yezzaji, H.; Aggarwal, M.; Dhamija, P.; Kumar, A.; Chisthi, M.; George, G.; Kollengode, V. V.; Kuttanchettiyar, K. G.; Yadev, I.; Dharanipragada, K.; Kalayarasan, R.; Penumadu, P.; Mathew, S.; Akhtar, N.; Chaturvedi, A.; Gupta, S.; Kumar, V.; Rajan, S.; Agrawal, N.; Arora, A.; Chaturvedi, H.; Jain, M.; Kumar, S.; Singh, S.; Bhat, G. A.; Chowdri, N.; Mehraj, A.; Parray, F. Q.; Shah, Z. A.; Wani, R.; Ahmed, Z.; Bhat, M. A.; Laharwal, A.; Mahmood, M.; Mir, I.; Mohammad, Z.; Muzamil, J.; Rashid, A.; Singh, R.; Ahmed, A.; Jain, D.; Pipara, A.; Desoouza, A.; Pandey, D.; Pramesh, C. S.; Saklani, A.; Islam, A. A.; Kembuan, G.; Pajan, H.; Aremu, M.; Canas-Martinez, A.; Cullivan, O.; Murphy, C.; Owens, P.; Pickett, L.; Corrigan, M.; Daly, A.; Fleming, C. A.; Jordan, P.; Kayyal, M. Y.; Killeen, S.; Lynch, N.; O'Brien, S.; Syed, W. A. S.; Vernon, L.; Hanly, A.; Heneghan, H.; Kennelly, R.; Martin, S. T.; Winter, D.; Fahey, B. A.; Larkin, J.; Mccormick, P.; Mehigan, B. J.; Mohan, H.; Shokuhi, P.; Smith, J.; Bashir, Y.; Bass, G.; Connelly, T.; Creavin, B.; Earley, H.; Elliott, J. A.; Gillis, A. E.; Kavanagh, D.; Neary, P.; O'Riordan, J.; Reynolds, I. S.; Rice, D.; Ridgway, P. F.; Umair, M.; Whelan, M.; Corless, K.; Finnegan, L.; Fowler, A.; Hogan, A.; Lowery, A.; McKevitt, K.; Nugent, E.; Ryan, E. J.; Coffey, J. C.; Cunningham, R. M.; Devine, M.; Nally, D.; Peirce, C.; Hardy, N. P.; Neary, P. M.; O'Malley, S.; Ryan, M.; Gaziants, V.; Gold-Deutch, R.; Lavy, R.; Zmora, O.; Macina, S.; Mariani, N. M.; Opocher, E.; Ceretti, Pisani A.; Bianco, F.; Marino, M.; Marino V, M.; Mirabella, A.; Vaccarella, G.; Sena, G.; Agostini, C.; Alemanno, G.; Bartolini, I.; Bergamini, C.; Bruscino, A.; De Vincenti, R.; Di Bella, A.; Fortuna, L.; Maltinti, G.; Muiesan, P.; Prosperi, P.; Ringressi, M. N.; Risaliti, M.; Taddei, A.; Tucci, R.; Campagnaro, T.; Guglielmi, A.; Pedrazzani, C.; Rattizzato, S.; Ruzzenente, A.; Turri, G.; Altomare, D. F.; Papagni, V.; Picciariello, A.; Bellora, P.; D'Aloisio, G.; Ferrari, M.; Francone, E.; Gentilli, S.; Nikaj, H.; Bianchini, M.; Chiarugi, M.; Coccolini, F.; Cremonini, C.; Di Franco, G.; Furbetta, N.; Gianardi, D.; Guadagni, S.; Morelli, L.; Musetti, S.; Palmeri, M.; Tartaglia, D.; Anania, G.; Carcoforo, P.; Chiozza, M.; De Troia, A.; Radica, Koleva M.; Portinari, M.; Sibilla, M. G.; Urbani, A.; Fabbri, N.; Feo V, C.; Gennari, S.; Parini, S.; Righini, E.; Annessi, V.; Ruiz, Castro C.; Giunta, A.; Montella, M. T.; Zizzo, M.; Grossi, U.; Novello, S.; Romano, M.; Rossi, S.; Zanus, G.; Esposito, G.; Frongia, F.; Pisanu, A.; Podda, M.; Belluco, C.; Lauretta, A.; Montori, G.; Moras, L.; Olivieri, M.; Feo, C. F.; Perra, T.; Porcu, A.; Scanu, A. M.; Aversano, A.; Carbone, F.; Delrio, P.; Di Lauro, K.; Bucci, Fares A.; Rega, D.; Spiezio, G.; Pirozzolo, G.; Recordare, A.; Vignotto, C.; Calabro, M.; Farnesi, F.; Lunghi, E. G.; Muratore, A.; Federico, Pipitone N. S.; De Palma, G.; Luglio, G.; Pagano, G.; Tropeano, F. P.; Baldari, L.; Boni, L.; Cassinotti, E.; Cosimelli, M.; Fiore, M.; Guaglio, M.; Sorrentino, L.; Agnes, A.; Alfieri, S.; Belia, F.; Biondi, A.; Cozza, V.; D'Ugo, D.; De Simone, V.; Litta, F.; Lorenzon, L.; Marra, A. A.; Marzi, F.; Parello, A.; Persiani, R.; Ratto, C.; Rosa, F.; Scrima, O.; Sganga, G.; Belli, A.; Izzo, F.; Patrone, R.; Foppa, C.; Carvello, M. M.; De Lucia, F.; Spinelli, A.; Aprile, A.; Batistotti, P.; Massobrio, A.; Pertile, D.; Scabini, S.; Soriero, D.; Garberini, De Manzoni A.; Mazzotti, F.; Pasini, F.; Ugolini, G.; Barone, R.; Birolo, S. L.; Caccetta, M.; Deirino, A.; Garino, M.; Grasso, M.; Marafante, C.; Masciandaro, A.; Moggia, E.; Mungo, S.; Murgese, A.; Raggio, E.; Federico, P.; Maida, P.; Marra, E.; Marte, G.; Petrillo, A.; Tammaro, P.; Tufo, A.; Berselli, M.; Borroni, G.; Cocozza, E.; Conti, L.; Desio, M.; Rizzi, A.; Baldi, C.; Corbellini, C.; Sampietro, G. M.; Bordoni, P.; Clarizia, G.; Fleres, F.; Franzini, M.; Grechi, A.; Longhini, A.; Spolini, A.; Baldini, E.; Capelli, P.; Isolani, S. M.; Ribolla, M.; Bondurri, A.; Colombo, F.; Ferrario, L.; Guerci, C.; Maffioli, A.; Armao, T.; Ballabio, M.; Bisagni, P.; Longhi, M.; Madonini, M.; Impellizzeri, H.; Inama, M.; Moretto, G.; Mochet, S.; Usai, A.; Incollingo, P.; Giacometti, M.; Zonta, S.; Cosentino, Marino L.; Sagnotta, A.; Lc, Nespoli; Tamini, N.; Anastasi, A.; Bartalucci, B.; Bellacci, A.; Canonico, G.; Capezzuoli, L.; Di Martino, C.; Ipponi, P.; Linari, C.; Montelatici, M.; Nelli, T.; Spagni, G.; Tirloni, L.; Vitali, A.; Abate, E.; Casati, M.; Laface, L.; Schiavo, M.; Arminio, A.; Cotoia, A.; Lizzi, V.; Vovola, F.; Vergari, R.; D'Ugo, S.; Depalma, N.; Spampinato, M. G.; Annicchiarico, A.; Catena, F.; Giuffrida, M.; Perrone, G.; Baronio, G.; Carissimi, F.; Montuori, M.; Pinotti, E.; Brachini, G.; Chiappini, A.; Cicerchia, P. M.; Cirillo, B.; De Toma, G.; Fiori, E.; Fonsi, G. B.; Iannone, I.; La Torre, F.; Lapolla, P.; Meneghini, S.; Mingoli, A.; Sapienza, P.; Zambon, M.; Capolupo, G. T.; Carannante, F.; Mazzotta, E.; Gattolin, A.; Migliore, M.; Rimonda, R.; Sasia, D.; Travaglio, E.; Chessa, A.; Fiorini, A.; Norcini, C.; Colletti, G.; Confalonieri, M.; Costanzi, A.; Frattaruolo, C.; Mari, G.; Monteleone, M.; Locatelli, A.; Riva, C.; Balconi, A.; De Nardi, P.; Parise, P.; Vignali, A.; Belvedere, A.; Bernante, P.; Droghetti, M.; Jovine, E.; Neri, J.; Parlanti, D.; Pezzuto, A. P.; Poggioli, G.; Rottoli, M.; Russo, I. S.; Tanzanu, M.; Violante, T.; Borghi, F.; Cianflocca, D.; Grimaldi, Di Maria S.; Donati, D.; Gelarda, E.; Giraudo, G.; Giuffrida, M. C.; Marano, A.; Palagi, S.; Pellegrino, L.; Peluso, C.; Testa, V.; Agresta, F.; Prando, D.; Zese, M.; Armatura, G.; Frena, A.; Bertelli, G.; Marinello, P.; Notte, F.; Scotton, G.; Cervellera, M.; Gori, A.; Sartarelli, L.; Tonini, V.; Gallo, G.; Sammarco, G.; Vescio, G.; Di Marzo, F.; Kanemitsu, Y.; Moritani, K.; Al Abdallah, M.; Ayasra, F.; Ayasra, Y.; Qasem, A.; Fahmawee, T.; Hmedat, A.; Obeidat, K.; Abou Chaar, M. K.; Al-Masri, M.; Al-Najjar, H.; Alawneh, F.; Aldokali, N.; Senossi, O.; Subhi, M. T.; Algallai, M.; Alwarfly, S.; AlZAEDE, S.; Gahwagi, M.; Moftah, M.; Burgan, D.; Kamoka, E.; Kilani I, A.; Abdelkabir, M.; Altomi, I.; Abdulwahed, E.; Alshareea, E.; Aribi, N.; Aribi, S.; Biala, M.; Ghamgh, R.; Alsoufi, A.; Ellojli, I.; Kredan, A.; Msherghi, A.; Alshareef, K.; Alkadiki, Ghadah Z.; Almaadany, Faraj S.; Bradulskis, S.; Dainius, E.; Kubiliute, E.; Parseliunas, A.; Subocius, A.; Venskutonis, D.; Rasoaherinomenjanahary, F.; Razafindrahita, J. B.; Samison, L. H.; Ngo, C. W.; Ramasamy, S.; Hamdan, K. H.; Razali I, Md; Tan, J. A.; Thanapal, M. R.; Choong, E.; Lim, R. Z. M.; Sahid, Nik Amin; Hayati, F.; Jayasilan, J.; Rk, Sriram; Subramaniam, S.; Ibrahim, A. F.; Jusoh, Che A.; Hussain, A. H.; Sidek, Mohamed A. S.; Yunus, Mohd M. F.; Soh, J. Y.; Wong, M. P.; Zakaria, A. D.; Zakaria, Z.; Azman, Mohd Z. A.; Fathi, N. Q.; Roslani, A. C.; Xavier, R.; Alvarez, M. R.; Cordera, F.; Hernandez, R.; Martinez, Soule C. E.; Hasan, Aboharp Z.; Otoniel, L. R.; Duran, Sosa E. E.; Melchor-Ruan, J.; Banuelos, Romero E.; Vilar-Compte, D.; Buerba, G. A.; Mercado, M. A.; Posadas-Trujillo, O. E.; Salgado-Nesme, N.; Sarre, C.; Amrani, L.; Benkabbou, A.; El Ahmadi, B.; El Bouazizi, Y.; Belkhadir, Z. H.; Ghannam, A.; Majbar, A. M.; Mohsine, R.; Souadka, A.; Hompes, R.; Meima-van Praag, E. M.; Pronk, A. J. M.; Sharabiany, S.; Grotenhuis, B. A.; Hartveld, L.; Ebben, L.; Kuiper, S.; Melenhorst, J.; Poeze, M.; Posma-Bouman, L.; Derksen, T.; Franken, J.; Oosterling, S.; Konsten, J.; Van Heinsbergen, M.; Adeyeye, A.; Enoch, E.; Nwabuoku, S. E.; Sholadoye, T. T.; Tolani, M. A.; Olaogun, J.; Abiyere, H.; Babalola, O.; Okunlola, A.; Sani, Ali S.; Chinda, J.; Garba, S.; Mshelbwala, P.; Olori, S.; Olute, A.; Osagie, O.; Ogolekwu I, Pius; Umar, A.; Lo, Abdur-Rahman; Jo, Bello; Olasehinde, O.; Popoola, A. 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K.; Yanishev, A.; Litvin, A.; Litvina, Y.; Provozina, A.; Agapov, M.; Garmanova, T.; Kazachenko, E.; Markaryan, D.; Galliamov, E.; Kakotkin, V.; Kubyshkin, V.; Semina, E.; Kamalov, A.; Novikova, A.; Zakharenko, A.; Alshahrani, M.; Alsharif, F.; Eskander, M.; Majrashi, S.; Mashat, A.; Alharthi, M.; Aljiffry, M.; Basendowah, M.; Malibary, N.; Nassif, M.; Samkari, A.; Trabulsi, N.; Azab, A. M.; Alqahtani, D.; Jaloun, H.; Mudawi, I.; Al Awwad, S.; Alghamdi, M.; Alnumani, T.; Awad, S.; Sharara, I. 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A.; Kara, H.; Karahasanoglu, T.; Uras, C.; Akbas, A.; Altinel, Y.; Calikoglu, F.; Ercan, G.; Ercetin, C.; Meric, S.; Tokocin, M.; Vartanoglu, T.; Yigitbas, H.; Dogangun, M.; Iflazoglu, N.; Cennet, O.; Ha, Dincer; Erol, T.; Alhamed, A.; Ergun, S.; Sanli, A. N.; Uludag, S. S.; Velidedeoglu, M.; Zengin, A. K.; Kara, Y.; Bozkurt, M. A.; Kocatas, A.; Eyuboglu, K.; Guner, A.; Usta, M. A.; Balik, E.; Bugra, D.; Kulle, C. B.; Guler, S. A.; Tatar, O. C.; Utkan, N. Z.; Yildirim, A.; Yuksel, E.; Abbasov, A.; Yanar, H.; Akin, E.; Altintoprak, F.; Cakmak, G.; Demir, H.; Dikicier, E.; Firat, N.; Gonullu, E.; Kamburoglu, M. B.; Kucuk, I. F.; Mantoglu, B.; Kucuk, G. O.; Uyanik, M. S.; Goksoy, B.; Bozkurt, E.; Capkinoglu, E.; Guven, O.; Mihmanli, M.; Omeroglu, S.; Tanal, M.; Yetkin, G.; Akalin, M.; Arican, C.; Avci, E. 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L.; Smith, C.; Vimalachandran, D.; Emslie, K.; Pl, Labib; Minto, G.; Natale, J.; Panahi, P.; Rogers, L. J.; Abubakar, A.; Rahman, Akhter M. M.; O'Brien, H.; Sasapu, K.; Ng, H. J.; Day, A.; Hunt, A.; Laskar, N.; Gupta, A.; Steinke, J.; Thrumurthy, S.; Massie, E.; McGivern, K.; Rutherford, D.; Wilson, M.; Bacarese-Hamilton, T.; Ip, M.; James, A.; Salerno, G.; Stockdale, T.; Handa, S.; Kaushal, M.; Kler, A.; Patel, P.; Redfern, J.; Tezas, S.; Aawsaj, Y.; Barry, C.; Blackwell, L.; Emerson, H.; Fisher, A.; Katory, M.; Mustafa, A.; Kretzmer, L.; Lalou, L.; Manku, B.; Parwaiz, I.; Stafford, J.; Abdelkarim, M.; Asqalan, A.; Gala, T.; Ibrahim, S.; Maw, A.; Mithany, R.; Morgan, R.; Venkatesan, Sundaram G.; Banfield, D.; Boal, M.; Brown, O.; Dean, H.; Boulton, A. J.; Hardie, C. M.; McNaught, C.; Karandikar, S.; Naumann, D.; Chen, F.; Cheung, J.; Ayorinde, J.; Chase, T.; Cuming, T.; Ghanbari, A.; Humphreys, L.; Tayeh, S.; Ibrahim, Aboelkassem A.; Evans, C.; Ikram, H.; Loubani, M.; Nazir, S.; Robinson, A.; Sehgal, T.; Wilkins, A.; Dixon, J.; Jha, M.; Thulasiraman V, S.; Viswanath, Y.; Curl-Roper, T.; Delimpalta, C.; Liao, C. C. L.; Velchuru, V.; Westwood, E.; Bond-Smith, G.; Mastoridis, S.; Tebala, G. D.; Verberne, C.; Anscomb, N.; Baldwin-Smith, R.; Davies, M.; Grainger, C.; Haji, A.; Haq, A.; Nunoo-Mensah, J. W.; Rizk, M.; Bhatti I, M.; Boyd-Carson, H.; Elsey, E.; Gemmill, E.; Herrod, P.; MohammedJibreel, M.; Lenzi, E.; Saafan, T.; Sapre, D.; Sian, T.; Watson, N.; Athanasiou, A.; Burke, J.; Costigan, F.; Elkadi, H.; Johnstone, J.; Nahm, C.; Annamalai, S.; Ashmore, C.; Kourdouli, A.; Chean, C. S.; Dharamavaram, S.; Kulkarni, N.; Pereira, I.; Shanthakunalan, K.; Srikumar, B.; Askari, A.; Cirocchi, N.; Kudchadkar, S.; Patel, K.; Sagar, J.; Talwar, R.; Abdalla, M.; Ismail, O.; Newton, K.; Stylianides, N.; Aderombi, A.; Bajomo, O.; Beatson, K.; Garrett V, W.; Ng, V.; Al-Habsi, R.; Divya, G. S.; Dixon, F.; Keeler, B. D.; Egan, R. J.; Fabre, I.; Harries, R.; Li, Z.; Parkins, K.; Spencer, N.; Thompson, D.; Gemmell, C.; Grieco, C.; Hunt, L.; Ali, Mahmoud F.; Seebah, K.; Shaikh, I.; Sreedharan, L.; Youssef, M.; Shah, J.; Baguley, M.; Heer, B.; Rogers, M.; Woods, R.; Mills, S. J.; Sahnan, K.; Ahmed, M. E.; Si, Bukhari; Illingworth, B.; Kanthasamy, S.; Knights, E.; Sl, Ong; Pujari, R.; Tan, K. H. M.; Vanker, R.; Michel, M.; Patil, S.; Ravindran, S.; Sarveswaran, J.; Scott, L.; Khan, J.; Bhangu, A.; Ld, Cato; Kamal, M.; Kulkarni, R.; Parente, A.; Saeed, S.; Vijayan, D.; English, C.; Evans, J.; Fell, A.; Halkias, C.; Merh, R.; Nikolaou, S.; Kaul, S.; Khan, A. H.; Khan, F.; Mukherjee, S.; Patel, M.; Sarigul, M.; Adiamah, A.; Brewer, H.; Chowdhury, A.; Humes, D.; Jackman, J.; Koh, A.; Lewis-Lloyd, C.; Oyende, O.; Reilly, J.; Worku, D.; Bisset, C.; Moug, S.; Chadha, R.; Math, S.; Sarantitis, I.; Timbrell, S.; Vitone, L.; Faulkner, G.; Brixton, G.; Findlay, L.; Majkowska, A.; Manson, J.; Potter, R.; Bhalla, A.; Chia, Z.; Daliya, P.; Grimley, E.; Malcolm, F. L.; Theophilidou, E.; Daniels, I. R.; Fowler, G. E.; Massey, L. H.; McDermott, F. D.; Rajaretnam, N.; Angamuthu, N.; Chowdhury, S.; Gilliland, J.; Hart, C.; Knowles, J.; Mirnezami, R.; Varcada, M.; Beamish, A. J.; Magowan, D.; Nassa, H.; Price, C.; Smith, L.; Solari, F.; Tang, A. M.; Williams, G.; Davies, E.; Hawkin, P.; Raymond, T.; Ryska, O.; Baron, R.; Gahunia, S.; McNicol, F.; Russ, J.; Szatmary, P.; Thomas, A.; Jayasinghe, J. D.; Knowles, C.; Ledesma, F. S.; Minicozzi, A.; Navaratne, L.; Ramamoorthy, R.; Sohrabi, C.; Thaha, M. A.; Venn, M.; Atherton, R.; Brocklehurst, M.; McAleer, J.; Parkin, E.; Aladeojebi, A.; Ali, M.; Gaunt, A.; Hammer, C.; Stebbing, J.; Coomber, E.; Williams, O.; Bunni, J.; Fairhurst, K.; Mitchell, S.; Richards, S.; Hraishawi, I.; McIlmunn, C.; McIntosh, S.; Bhasin, S.; Bodla, A. S.; Burahee, A.; Crichton, A.; Fossett, R.; Yassin, N.; Barlow, C.; Ding, D.; Foster, J.; Longstaff, L.; Brown, S. R.; Lee, M.; Newman, T.; Steele, C.; Baker, A.; Konstantinou, C.; Ramcharan, S.; Wilkin, R. J. W.; Colvin V, H.; Shakoor, Z.; Lawday, S.; Lyons, A.; Newman, S.; Chung, E.; Hagger, R.; Hainsworth, A.; Karim, A.; Owen, H.; Ramwell, A.; Williams, K.; Hall, J.; Harris, G.; Royle, T.; Lj, Watson; Asaad, P.; Brown, B.; Duff, S.; Khan, A.; Moura, F.; Wadham, B.; Mccluney, S.; Parmar, C.; Shah, S.; Babar, M. S.; Goodrum, S.; Whitmore, H.; Balasubramaniam, D.; Jayasankar, B.; Kapoor, S.; Ramachandran, A.; Beech, N.; Chand, M.; Green, L.; Kiconco, H.; McEwen, R.; Pereca, J.; Arumugam, S.; Ibrahim, B.; Khan, K.; Gash, K.; Gourbault, L.; Maccabe, T. A.; Newton, C.; Baig, M.; Bates, H.; Dunne, N.; Khajuria, A.; Dr, Sarma; Shortland, T.; Tewari, N.; Akhtar, M. A.; Brunt, A.; McIntyre, J.; Milne, K.; Rashid, M. M.; Sgro, A.; Stewart, K. E.; Turnbull, A.; Gossedge, G.; O'Donnell, S.; Oldfield, F.; Gonzalez, Aguilar M.; Talukder, S.; Eskander, P.; Hanna, M.; Olivier, J.; Basnyat, P.; Davis, H.; Montauban, P.; Shrestha, A.; Magee, C.; Powell, S.; Flindall, I.; Hanson, A.; Mahendran, V.; Green, S.; Lim, M.; MacDonald, L.; Miu, V.; Onos, L.; Sheridan, K.; Young, R.; Alam, F.; Griffiths, O.; Houlden, C.; Kolli, V. S.; Lala, A. K.; Seymour, Z.; Consorti, E.; Gonzalez, R.; Kwan-Feinberg, R.; Liu, T.; Cooper, Z.; Hirji, S.; Mahvi, D.; Okafor, B.; Roxo, V.; Salim, A.; Loehrer, A.; Telma, K.; Bokenkamp, M.; Haynes, A. B.; Hill, C.; Leede, E.; McElhinney, K.; Olson, K. A.; Riley, C.; Bigelow, B.; Etchill, E. W.; Gabre-Kidan, A.; Jenny, H. E.; Kent, A.; Ladd, M. R.; Long, C.; Malapati, H.; Margalit, A.; Rapaport, S.; Rose, J.; Stevens, K.; Tsai, L.; Vervoort, D.; Yesantharao, P.; Klaristenfeld, D.; Huynh, K. T.; Kaafarani, H.; Naar, L.; Qadan, M.; Cha, D. E.; Gleeson, E.; Horn, C.; Sarpel, U.; Bhama, A.; Colling, K.; Najarian, M.; Azam, M.; Choudhry, A.; Marx, W.; Chokshi, R.; Glass, N.; Tsui, G.; Abel, M. K.; Boeck, M.; Chern, H.; Kornblith, L. Z.; Nunez-Garcia, B.; Ozgediz, D.; Sarin, A.; Varma, M. G.; Abbott, D.; Acher, A.; Aiken, T.; Barrett, J.; Foley, E.; Schwartz, P. B.; Zafar, S. N.; Hawkins, A. T.; Maiga, A.; Ruzgar, N. M.; Sion, M.; Ullrich, S.; Al-Naggar, H.; Al-Shehari, M.; Almassaudi, A.; Alsayadi, M.; Alsayadi, R.; Shream, S.; Uberruck, L.; Angelo, M.; Alga, A.; Celebi, F.; Colak, E.; Ogucu, H.; Arulanantham, A.; Bandara, G. B. K. D.; Jayarajah, U.; Ravindrakumar, S.; Rodrigo, V. S. D.; Collaborative, COVIDSurg; EuroSurg; European Soc Coloproctology, E. S. C. P.; Surg, Global Initiative Children's; GlobalSurg; GlobalPaedSurg; ItSURG; PTSurg; SpainSurg; SICCR, Italian Soc Colorectal Surg; ASiT, Assoc Surg Training; Irish Surg Res Collaborative, I. S. R. C.; Retrope, Transatlantic Australasian; Italian Soc Surg Oncology, S. I. C. O.
    Aim The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. Methods This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. Results Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6\% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5\% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7\% vs. 91.9\%, P = 0.032) and lower rates of emergency surgery (4.5\% vs. 22.5\%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95\% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95\% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. Conclusion One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease.
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    Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society
    (SPRINGER, 2022-01-01) Akin, Ilke Mungan; Kanburoglu, Mehmet Kenan; Tayman, Cuneyt; Oncel, Mehmet Yekta; Imdadoglu, Timucin; Dilek, Mustafa; Yaman, Akan; Narter, Fatma; Er, Ilkay; Kahveci, Hasan; Erdeve, Omer; Koc, Esin; Grp, Neo-Covid Study
    The literature on neonates with SARS-CoV-2 is mainly concerned with perinatal cases, and scanty data are available about environmentally infected neonates. To fill knowledge gaps on the course and prognosis of neonatal cases, we analyzed 1-year data from the Turkish Neonatal Society in this prospective cohort study of neonates with postnatal transmission. Data from 44 neonatal intensive care units (NICUs), of neonates with positive RT-PCR results at days 5-28 of life, were extracted from the online registry system and analyzed. Of 176 cases, most were term infants with normal birth weight. Fever was the most common symptom (64.2\%), followed by feeding intolerance (25.6\%), and cough (21.6\%). The median length of hospitalization was 9 days, with approximately one quarter of infants receiving some type of ventilatory support. Myocarditis (5.7\%) was the most common complication during follow-up. Among the clinical findings, cough (odds ratio {[}OR]: 9.52, 95\% confidence interval {[}CI]: 4.17-21.71), tachypnea (OR: 26.5, 95\% CI: 9.59-73.19), and chest retractions (OR: 27.5, 95\% CI: 5.96-126.96) were associated with more severe clinical disease. Also, there were significant differences in the C-reactive protein level, prothrombin time (PT), partial thromboplastin time, international normalized ratio, and days in the NICU (p = 0.002, p = 0.012, p = 0.034, p = 0.008, and p < 0.001, respectively) between patients with mild-moderate and severe-critical presentations. A PT above 14 s was a significant predictor of severe/critical cases, with a sensitivity of 64\% and specificity of 73\%. Conclusions: Our data showed that late-onset COVID-19 infection in neonates who need hospitalization can be severe, showing associations with high rates of ventilatory support and myocarditis. Cough, tachypnea, and retractions on admission suggest a severe disease course.
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    Efficacy and safety profile of COVID-19 vaccine in cancer patients: a prospective, multicenter cohort study
    (FUTURE MEDICINE LTD, 2022-01-01) Yasin, Ayse Irem; Aydin, Sabin Goktas; Sumbul, Bilge; Koral, Lokman; Simsek, Melih; Geredeli, Caglayan; Ozturk, Akin; Perkin, Perihan; Demirtas, Derya; Erdemoglu, Engin; Hacibekiroglu, Ilhan; Cakir, Emre; Tanrikulu, Eda; Coban, Ezgi; Ozcelik, Melike; Celik, Sinemis; Teker, Fatih; Aksoy, Asude; Firat, Sedat T.; Tekin, Omer; Kalkan, Ziya; Turken, Orhan; Oven, Bala B.; Dane, Faysal; Bilici, Ahmet; Isikdogan, Abdurrahman; Seker, Mesut; Turk, Haci M.; Gumus, Mahmut
    Aim: To compare the seropositivity rate of cancer patients with non-cancer controls after inactive SARS-CoV-2 vaccination (CoronaVac) and evaluate the factors affecting seropositivity. Method: Spike IgG antibodies against SARS-CoV-2 were measured in blood samples of 776 cancer patients and 715 non-cancer volunteers. An IgG level >= 50 AU/ml is accepted as seropositive. Results: The seropositivity rate was 85.2\% in the patient group and 97.5\% in the control group. The seropositivity rate and antibody levels were significantly lower in the patient group (p < 0.001). Age and chemotherapy were associated with lower seropositivity in cancer patients (p < 0.001). Conclusion: This study highlighted the efficacy and safety of the inactivated vaccine in cancer patients. Clinical Trials Registration: ClinicalTrials.gov) Plain language summary Cancer patients are at high risk for infection with SARS-CoV-2 and of developing the associated disease, COVID-19, which therefore puts them in the priority group for vaccination. This study evaluated the efficacy and safety of CoronaVac, an inactivated virus vaccine, in cancer patients. The immune response rate, defined as seropositivity, was 85.2\% in the cancer patient group and 97.5\% in the control group. The levels of antibodies, which are blood markers of immune response to the vaccine, were also significantly lower in the patient group, especially in those older than 60 years and receiving chemotherapy. These results highlight the importance of determining the effective vaccine type and dose in cancer patients to protect them from COVID-19 without disrupting their cancer treatment.
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    Allergic diseases and immunodeficiencies in children, lessons learnt from COVID-19 pandemic by 2022: A statement from the EAACI-section on pediatrics
    (WILEY, 2022-01-01) Munblit, Daniel; Greenhawt, Matthew; Brough, Helen A.; Pushkareva, Anna; Karimova, Diana; Demidova, Anastasia; Warner, John O.; Kalayci, Omer; Sediva, Anna; Untersmayr, Eva; Rodriguez del Rio, Pablo; Vazquez-Ortiz, Marta; Arasi, Stefania; Alvaro-Lozano, Montserrat; Tsabouri, Sophia; Galli, Elena; Beken, Burcin; Eigenmann, Philippe A.
    By the April 12, 2022, the COVID-19 pandemic had resulted in over half a billion people being infected worldwide. There have been 6.1 million deaths directly due to the infection, but the pandemic has had many more short- and long-term pervasive effects on the physical and mental health of the population. Allergic diseases are among the most prevalent noncommunicable chronic diseases in the pediatric population, and health-care professionals and researchers were seeking answers since the beginning of pandemic. Children are at lower risk of developing severe COVID-19 or dying from infection. Allergic diseases are not associated with a higher COVID-19 severity and mortality, apart from severe/poorly controlled asthma. The pandemic disrupted routine health care, but many mitigation strategies, including but not limited to telemedicine, were successfully implemented to continue delivery of high-standard care. Although children faced a multitude of pandemic-related issues, allergic conditions were effectively treated remotely while reduction in air pollution and lack of contact with outdoor allergens resulted in improvement, particularly respiratory allergies. There is no evidence to recommend substantial changes to usual management modalities of allergic conditions in children, including allergen immunotherapy and use of biologicals. Allergic children are not at greater risk of multisystem inflammatory syndrome development, but some associations with Long COVID were reported, although the data are limited, and further research is needed. This statement of the EAACI Section on Pediatrics provides recommendations based on the lessons learnt from the pandemic, as available evidence.
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    Comparison of a novel antigen detection test with reverse transcription polymerase chain reaction assay for laboratory diagnosis of SARS-CoV-2 infection
    (SPRINGER HEIDELBERG, 2022-01-01) Cirit, Osman Sezer; Mutlu, Esvet; Sancak, Banu; Kocagoz, Tanil; Can, Ozge; Cicek, Candan; Sayiner, Ayca Arzu; Appak, Ozgur; Uyar, Neval Yurttutan; Kulah, Canan; Cicek, Aysegul Copur; Ozgumus, Osman Birol; Altintop, Yasemin Ay; Saatci, Esma; Karsligil, Tekin; Zer, Yasemin; Ozen, Nevgun Sepin; Cekin, Yesim; Karahan, Zeynep Ceren; Evren, Ebru; Karakoc, Ayse Esra; Orhan, Sultan Gulbahce; Mutlu, Derya; Bozdemir, Tugba; Cayci, Yeliz Tanriverdi; Cinar, Canberk; Tasbakan, Meltem; Mert, Merve; Cinar, Ece; Kutsoylu, Oya Ozlem Eren; Kocagoz, Sesin; Erturk, Ayse; Celik, Ilhami; Mete, Ayse Ozlem; Eneyli, Muge Gunalp; Akdemir, Irem; Karakok, Taliha; Inan, Dilara; Atilla, Aynur; Taflan, Sevket Onur; Yoruk, Kagan Etka
    Molecular diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by real-time reverse transcription polymerase chain reaction (RT-PCR) in respiratory specimens is considered the gold standard method. This method is highly sensitive and specific but it has some limitations such as being expensive and requiring special laboratory equipment and skilled personnel. RapidFor (TM) Antigen Rapid Test Kit is a commercially available Ag-RDT which is produced in Turkey and designed to detect the nucleocapsid antigen of SARS-CoV-2 in nasopharyngeal swab samples. The aim of this study was to evaluate the performance of this novel SARS-CoV-2 antigen detection considering the RT-PCR method as the gold standard. Four hundred forty-four nasopharyngeal swab samples which were collected from the patients who met clinical criteria of COVID-19 from ten centers in Turkey between September 2020 and February 2021 were included in the study. All the nasopharyngeal swab samples were tested for SARS-CoV-2 RNA using commercial RT-PCR kits (Bioeksen and A1 Lifesciences, Istanbul, Turkey) according to the manufacturer's instructions. Viral loads were assessed according to the cycle threshold (Ct) values. RapidFor (TM) SARS-CoV-2 antigen test (Vitrosens Biotechnology, Istanbul, Turkey) was used to investigate the presence of SARS-CoV-2 antigen in all samples following the manufacturer's instructions. Out of 444 nasopharyngeal swab samples tested, 346 (77.9\%) were positive and 98 (22.1\%) were negative for SARS-CoV-2 RNA by RTPCR. Overall sensitivity of the RapidFor (TM). Antigen Rapid Test Kit was 80.3\% whereas specificity was found to be 87.8\%. Positivity rate of rapid antigen test in samples with Ct values over 25 and below 30 was 82.7\%, while it increased to 95.7\% in samples 20 <= Ct < 25 and reached 100\% in samples with Ct values below 20. RapidFor (TM) SARS-CoV-2 Ag test might be a good choice in the screening of symptomatic and asymptomatic patients and their contacts for taking isolation measures early, with advantages over RT-PCR as being rapid, easy and being applicable in every laboratory and even at point of care.
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    Olfactory Cleft Measurements and COVID-19-Related Anosmia
    (SAGE PUBLICATIONS INC, 2021-01-01) Altundag, Aytug; Yildirim, Duzgun; Sanli, Deniz Esin Tekcan; Cayonu, Melih; Kandemirli, Sedat Giray; Sanli, Ahmet Necati; Duz, Ozge Arici; Saatci, Ozlem
    Objective. This study aimed to investigate the differences in olfactory cleft (OC) morphology in coronavirus disease 2019 (COVID-19) anosmia compared to control subjects and postviral anosmia related to infection other than severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study Design. Prospective. Setting. This study comprises 91 cases, including 24 cases with anosmia due to SARS-CoV-2, 38 patients with olfactory dysfunction (OD) due to viral infection other than SARS-CoV-2, and a control group of 29 normosmic cases. Methods. All cases had paranasal sinus computed tomography (CT), and cases with OD had magnetic resonance imaging (MRI) dedicated to the olfactory nerve. The OC width and volumes were measured on CT, and T2-weighted signal intensity (SI), olfactory bulb volumes, and olfactory sulcus depths were assessed on MRI. Results. This study showed 3 major findings: the right and left OC widths were significantly wider in anosmic patients due to SARS-CoV-2 (group 1) or OD due to non-SARS-CoV-2 viral infection (group 2) when compared to healthy controls. OC volumes were significantly higher in group 1 or 2 than in healthy controls, and T2 SI of OC area was higher in groups 1 and 2 than in healthy controls. There was no significant difference in olfactory bulb volumes and olfactory sulcus depths on MRI among groups 1 and 2. Conclusion. In this study, patients with COVID-19 anosmia had higher OC widths and volumes compared to control subjects. In addition, there was higher T2 SI of the olfactory bulb in COVID-19 anosmia compared to control subjects, suggesting underlying inflammatory changes. There was a significant negative correlation between these morphological findings and threshold discrimination identification scores.
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    Impact of proactive low-molecular weight heparin therapy on outcomes in COVID-19
    (AEPRESS SRO, 2021-01-01) Gormez, S.; Gumusel, H. K.; Ekicibasi, E.; Degirmencioglu, A.; Paudel, A.; Akan, G.; Atalar, F.; Erdim, R.; Eroglu, E.; Dagdelen, S.; Sariguzel, N.; Kirisoglu, C. E.; Pamukcu, B.
    OBJECTIVES: Low molecular weight heparin (LMWH) may provide beneficial effects on outcomes of COVID-19. We aimed to examine the impact of LMWH treatment on clinical outcomes (duration of hospitalization, admission to intensive care unit, the requirement for mechanical ventilation, and death) of COVID-19 patients with normal D-dimer levels at admission. BACKGROUND: Coronavirus disease-2019 (COVID-19) predisposes patients to arterial and venous thrombosis. METHODS: In this retrospective, multicentre and observational study we analysed the data of 308 confirmed COVID-19 patients with normal D-dimer levels at initial admission. After propensity score matching (PSM) patients were grouped
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    Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection
    (MDPI, 2020-01-01) Palmeira, Andreia; Sousa, Emilia; Koseler, Aylin; Sabirli, Ramazan; Goren, Tarik; Turkcuer, Ibrahim; Kurt, Ozgur; Pinto, Madalena M.; Helena Vasconcelos, M.
    SARS-CoV-2 Spike protein was predicted by molecular docking to bind the host cell surface GRP78, which was suggested as a putative good molecular target to inhibit Covid-19. We aimed to confirm that GRP78 gene expression was increased in blood of SARS-CoV-2 (+) versus SARS-CoV-2 (-) pneumonia patients. In addition, we aimed to identify drugs that could be repurposed to inhibit GRP78, thus with potential anti-SARS-CoV-2 activity. Gene expression studies were performed in 10 SARS-CoV-2 (-) and 24 SARS-CoV-2 (+) pneumonia patients. A structure-based virtual screen was performed with 10,761 small molecules retrieved from DrugBank, using the GRP78 nucleotide binding domain and substrate binding domain as molecular targets. Results indicated that GRP78 mRNA levels were approximately four times higher in the blood of SARS-CoV-2 (+) versus SARS-CoV-2 (-) pneumonia patients, further suggesting that GRP78 might be a good molecular target to treat Covid-19. In addition, a total of 409 compounds were identified with potential as GRP78 inhibitors. In conclusion, we found preliminary evidence that further proposes GRP78 as a possible molecular target to treat Covid-19 and that many clinically approved drugs bind GRP78 as an off-target effect. We suggest that further work should be urgently carried out to confirm if GRP78 is indeed a good molecular target and if some of those drugs have potential to be repurposed for SARS-CoV-2 antiviral activity.
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    A cross-sectional overview of SARS-CoV-2 genome variations in Turkey
    (WALTER DE GRUYTER GMBH, 2021-01-01) Ergunay, Koray; Kaya, Mucahit; Serdar, Muhittin; Akyon, Yakut; Yilmaz, Engin
    Objectives: We assessed SARS-CoV-2 genome diversity and probable impact on epidemiology, immune response and clinical disease in Turkey. Materials and methods: Complete genomes and partial Spike (S) sequences were accessed from the Global Initiative on Sharing Avian Influenza Data (GISAID) database. The genomes were analysed for variations and recombinations using appropriate softwares. Results: Four hundred ten complete genomes and 206 S region sequences were included. Overall, 1,200 distinct nucleotide variations were noted. Mean variation count was 14.2 per genome and increased significantly during the course of the pandemic. The most frequent variations were identified as A23403G (D614G
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    Targeting SARS-CoV-2 infection through CAR-T-like bispecific T cell engagers incorporating ACE2
    (WILEY, 2022-01-01) Dogan, Mikail; Kozhaya, Lina; Placek, Lindsey; Karabacak, Fatih; Yigit, Mesut; Unutmaz, Derya
    Objectives. Despite advances in antibody treatments and vaccines, COVID-19 caused by SARS-CoV-2 infection remains a major health problem resulting in excessive morbidity and mortality and the emergence of new variants has reduced the effectiveness of current vaccines. Methods. Here, as a proof-of-concept, we engineered primary CD8 T cells to express SARS-CoV-2 Spike protein-specific CARs, using the extracellular region of ACE2 and demonstrated their highly specific and potent cytotoxicity towards Spike-expressing target cells. To improve on this concept as a potential therapeutic, we developed a bispecific T cell engager combining ACE2 with an anti-CD3 scFv (ACE2-Bite) to target infected cells and the virus. Results. As in CAR-T cell approach, ACE2-Bite endowed cytotoxic cells to selectively kill Spike-expressing targets. Furthermore, ACE2-Bite neutralized the pseudoviruses of SARS-CoV, SARS-CoV-2 wild-type, and variants including Delta and Omicron, as a decoy protein. Remarkably, ACE2-Bite molecule showed a higher binding and neutralization affinity to Delta and Omicron variants compared to SARS-CoV-2 wild-type Spike proteins. Conclusion. In conclusion, these results suggest the potential of this approach as a variant-proof, therapeutic strategy for future SARS-CoV-2 variants, employing both humoral and cellular arms of the adaptive immune response.