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    Comparison of factor XII levels in gestational diabetes, fetal macrosomia, and healthy pregnancies
    (BMC, 2020-01-01) Ozbasli, Esra; Takmaz, Ozguc; Karabuk, Emine; Gungor, Mete
    BackgroundIf not detected and treated, gestational diabetes mellitus (GDM) can cause serious pregnancy complications such as macrosomia, preeclampsia, and fetal/neonatal mortality. Many studies have examined underlying contributing factors for GDM, including hypercoagulation. Factor XII (FXII) is a coagulation factor that increases throughout normal pregnancies, and we evaluated the relationship of GDM with FXII, FXIIa (activated FXII), and other coagulation parameter levels. GDM and macrosomia are closely related, but it is not known whether FXII could be an independent causal factor for macrosomia.MethodsIn this prospective study, blood samples were taken from 69 pregnant women at the time of term delivery to determine levels of FXII, FXIIa, and other coagulation parameters. Based on the results, pregnancies fell into GDM, non-diabetic with macrosomia (M), or healthy (C {[}control]).ResultsFXII concentration levels were significantly higher in GDM patients compared with the M and C groups. There were no significant differences when comparing FXIIa, activated partial thromboplastin time, prothrombin time (PT), and international normalized ratio. The GDM group saw a significant negative correlation between FXII concentrations and maternal pregestational body mass index (BMI) and BMI before delivery. In the M group, a positive correlation was observed between FXII concentrations and newborn weight and newborn weight percentile.ConclusionsAn increase in FXII levels was observed in patients with gestational diabetes. Associations between coagulation parameters and GDM should be further analyzed to define the mechanisms of GDM and possible treatment modalities.Trial registrationOur study has been registered at clinicaltrials.gov (NCT03583216). Registered on July 11, 2018,
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    Transient osteoporosis of pregnancy: case report
    (GALENOS YAYINCILIK, 2010-01-01) Ergin, Tolga; Selam, Belgin; Lembet, Arda; Ozturk, Harika Bodur; Damlacik, Atilla; Demirel, Cem
    Transient osteoporosis of pregnancy is a rarely observed skeletal pathology developing in the last months of pregnancy. Meticulous evaluation is important for the differential diagnosis of severe and progressive hip and/or groin pain in pregnant patients. MRI is a valuable and safe technique for demonstrating bone marrow edema and skeletal abnormalities during pregnancy. Avoidance of vaginal delivery and non-weight bearing measures are essential in order to prevent complications such as hip fractures related to transient osteoporosis of pregnancy. We present the diagnostic evaluation and treatment of an uncommon case of transient osteoporosis of pregnancy with resolution of symptoms and postpartum.
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    Effects of Normal Morphology Sperm Count on Fertilization Time in Infertile Couples with Teratospermic Males: An Evaluation with an Embryoscope
    (GALENOS YAYINCILIK, 2022-01-01) Aygun, Elif Ganime; Karabuk, Emine
    Objective: Incubation of the embryo is the vital step in assisted reproductive techniques. Embryoscope systems are incubators that keep the embryo stable and allow for continuous observation without opening the lid. Therefore, the embryo is not displaced and goes through a temperature or air change. The primary aim of this study was to explore the effects of normal morphology sperm count on two pronucleus formation time following intracytoplasmic sperm injection in infertile couples with teratospermic males. The secondary aim was clinical pregnancy. Materials and Methods: Sixty-seven couples undergoing in vitro fertilization were included in this retrospective cohort study. First, intracytoplasmic sperm injection was performed to metaphase II-oocytes. Then, the embryos were placed in an embryoscope (a time-lapse system) for observation. The time that embryos demonstrated two pronuclei were recorded. Demographic and reproductive data were obtained and analyzed. Results: A statistically significant weak correlation was detected between sperm morphology the two pronucleus formation times (r=0.295, p=0.017). Severely decreased normal sperm count was significantly associated with pregnancy with less decreased normal sperm count (p>0.024). Moreover, decreased two pronucleus formation time was significantly associated with pregnancy. Conclusion: A statistically significant, albeit weak, correlation was detected between sperm morphology with two pronucleus formation time. Furthermore, having a lower normal sperm count was related to a higher pregnancy rate than having a higher normal sperm count. Lastly, reduced two pronucleus formation time was significantly associated with pregnancy.