WOS

Permanent URI for this collectionhttps://hdl.handle.net/11443/932

Browse

Has files: YesSubject: search.filters.subject.rat

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Comparison of warm fluid and cold fluid resuscitation during uncontrolled hemorrhagic shock model in rats
    (TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2017-01-01) Dilmen, Serkan; Eryilmaz, Mehmet; Balkan, Salih Mujdat; Serdar, Muhittin; Durusu, Murat; Yildirim, Ali Osman; Dilmen, Sanem Aslihan
    BACKGROUND: This study was designed to compare the effects of resuscitation with cold and warm fluid on survival time, rate and volume of hemorrhage, hemodynamics, hypothermia, coagulopathy, acid-base balance, hematocrit, lactate, and base deficit during uncontrolled hemorrhagic shock (HS) model in rats. METHODS: HS model was created with splenic vascular and parenchymal injury in 29 rats under ketamine and xylazine anesthesia. Thirty minutes after the hemorrhage, the rats were randomized to receive 14.5 mL/kg 0.9\% sodium chloride solution at either 24 degrees C (Group I
  • Thumbnail Image
    Item
    Oral tadalafil reduces intra-abdominal adhesion reformation in rats
    (OXFORD UNIV PRESS, 2012-01-01) Kutuk, Mehmet Serdar; Ozgun, Mahmut Tuncay; Batukan, Cem; Ozcelik, Bulent; Basbug, Mustafa; Ozturk, Ahmet
    Currently, there is no ideal agent to prevent adhesion formation. We have shown that sildenafil, a phosphodiesterase-5 (PDE-5) inhibitor, reduces post-operative adhesion formation by vasodilatation and increases fibrinolytic activity. Here, we evaluated whether tadalafil, a long-acting PDE-5 inhibitor, decreases post-operative adhesion reformation in rats. Standardized lesions were created in Wistar albino rats by cauterization of uterine horns and abrasion of adjacent peritonium. The extent and severity of adhesions were scored on the 14th post-operative day and adhesiolysis was performed at the second laparotomy. Animals were then assigned randomly into two groups. The study group (n 11) received 10 mg/kg oral tadalafil by gavage 60 min before the second laparotomy and daily for 14 days afterwards. Controls (n 11) received the same volume of tap water for 14 days by gavage. Animals were killed 15 days after adhesiolysis and adhesions were scored blind during the third laparotomy. Basal adhesion scores at the time of the second laparotomy were comparable in the study and control groups. Scores for the extent of adhesion reformation in the study and control groups did not differ {[}median 1 (range 03) versus median 2 (range 13)