Araştırma Çıktıları
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Item Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study(TURKISH SOC CARDIOLOGY, 2011-01-01) Buturak, Ali; Genc, Ahmet; Ulus, Ozden Sila; Duygu, Egemen; Okmen, Arda Sanli; Uyarel, HuseyinObjective: To evaluate the effect of chronic biomass fuel (BMF) smoke exposure on peripheral endothelial functions. Methods: Forty-seven healthy subjects who have been exposed to BMF smoke since birth (mean age 31.6 +/- 6.8 years, 21 male) were enrolled in the present cross-sectional observational study. The control group consisted of 32 healthy subjects (mean age 27.9 +/- 4.4 years, 11 male). The carotid intima media thickness (CIMT), flow associated dilatation (FAD \%) and endothelium independent vasodilatation (GTN \%) were assessed in all subjects. The carotid CIMT was defined as the distance between the leading edge of the lumen intima and the media adventitia interfaces. FAD \% was defined as the percentage change in the internal diameter of the brachial artery during reactive hyperemia related to the baseline. GTN \% was defined as the change in diameter in response to the application of 400 mu g of glyceril trinitrate relative to the baseline scan at the end of the fourth minute. Statistical analysis was performed using Student's t-test, Chi-square test and Spearman rank order correlation analysis. Results: The average exposure time of the subjects to biomass fuel smoke was 31.7 +/- 6.6 years. They have been exposed to dung inhalation products meanly 8.3 +/- 1.8 months in a year seasonally. The average daily exposure time was 15.7 +/- 3.3 hours. CIMT values of the two groups were not statistically different from each other (0.47 +/- 0.09 vs. 0.49 +/- 0.06 mm, p=0.138). However, a markedly reduced FAD \% was determined in the study group (5.06 +/- 4.95 vs. 10.7 +/- 4.64, p < 0.001). And GTN \% of the BMF exposed group was significantly lower than the control group (14.41 +/- 8.47 vs. 21.85 +/- 7.87, p < 0.001). Conclusion: FAD \% and GTN \% are markedly reduced in the individuals who have been exposed to BMF smoke inhalation products. Therefore, chronic BMF smoke exposure may be a risk factor for the development of endothelial dysfunction. (Anadolu Kardiyol Derg 2011Item Comparison of anti-embolic protection with proximal balloon occlusion and filter devices during carotid artery stenting: clinical and procedural outcomes(TERMEDIA PUBLISHING HOUSE LTD, 2013-01-01) Tatli, Ersan; Buturak, Ali; Grunduz, Yasemin; Dogan, Emir; Alkan, Mustafa; Sayin, Murat; Yilmaztepe, Mustafa; Atakay, SelcukAim: The objective of this study was to compare the periprocedural and clinical outcomes after carotid artery stenting (CAS) with proximal protection devices versus with distal protection devices. Material and methods: Patients with internal carotid artery (ICA) stenosis undergoing CAS with cerebral embolic protection were randomly assigned to proximal balloon occlusion or distal filter protection. Adverse events were defined as death, major stroke, minor stroke, transient ischemic attack (TIA) and myocardial infarction (MI). Periprocedural and 30-day adverse events and ICA vasospasm rates were compared between the two embolic protection groups. Results: Eighty-eight consecutive patients were randomized: 48 patients with proximal protection (mean age 68.8 +/- 13.6, 66\% male) and 40 patients with a distal protection device (mean age 65.4 +/- 12.3Item Arrhythmias following Revascularization Procedures in the Course of Acute Myocardial Infarction: Are They Indicators of Reperfusion or Ongoing Ischemia?(HINDAWI LTD, 2013-01-01) Tatli, Ersan; Alicik, Guray; Buturak, Ali; Yilmaztepe, Mustafa; Aktoz, MeryemObjective. The most important step in the treatment of ST elevation myocardial infarction is to sustain myocardial blood supply as soon as possible. The two main treatment methods used today to provide myocardial reperfusion are thrombolytic therapy and percutaneous coronary intervention. In our study, reperfusion arrhythmias were investigated as if they are indicators of coronary artery patency or ongoing ischemia after revascularization. Methods. 151 patients with a diagnosis of acute ST elevation myocardial infarction were investigated. 54 patients underwent primary percutaneous coronary intervention and 97 patients were treated with thrombolytic therapy. The frequency of reperfusion arrythmias following revascularization procedures in the first 48 hours after admission was examined. The relation between reperfusion arrhythmias, ST segment regression, coronary artery patency, and infarct related artery documented by angiography were analyzed. Results. There was no statistically significant difference between the two groups in the frequency of reperfusion arrhythmias (P = 0.355). Although angiographic vessel patency was higher in patients undergoing percutaneous coronary intervention, there was no significant difference between the patency rates of each group with and without reperfusion arrythmias. Conclusion. Our study suggests that recorded arrhythmias following different revascularization procedures in acute ST elevation myocardial infarction may not always indicate vessel patency and reperfusion. Ongoing vascular occlusion and ischemia may lead to various arrhythmias which may not be distinguished from reperfusion arrhythmias.Item Assessment of Subclinical Left and Right Ventricular Dysfunction by Using Isovolumic Acceleration in Patients with Dipper and Non-dipper Hypertensives(2013-01-01) Erturk, Mehmet; Buturak, Ali; Pusuroglu, Hamdi; Kalkan, Ali Kemal; Gurdogan, Muhammet; Uzun, Fatih; Akgul, Ozgur; Aksu, Hale Unal; Akturk, Faruk; Uslu, NevzatItem The Long Term Incidence and Predictors of Radial Artery Occlusion Following a Transradial Coronary Procedure(2013-01-01) Buturak, Ali; Gorgulu, Sevket; Norgaz, Tugrul; Voyvoda, Nuray; Sahingoz, Yusuf; Degirmencioglu, Alex; Demirci, Yasemin; Dagdelen, SinanItem Comparison of Anti- Embolic Protection with Proximal Balloon Occlusion and Filter Devices During Carotid Artery Stenting: Clinical and Procedural Outcomes(2013-01-01) Tatli, Ersan; Buturak, Ali; Dogan, Emir; Alkan, Mustafa; Sayin, Murat; Yilmaztepe, Mustafa; Atakay, Selcuk