Araştırma Çıktıları

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    Effects of intra-articular administration of autologous bone marrow aspirate on healing of full-thickness meniscal tear: an experimental study on sheep
    (TURKISH ASSOC ORTHOPAEDICS TRAUMATOLOGY, 2012-01-01) Duygulu, Fuat; Demirel, Metin; Atalan, Gultekin; Kaymaz, F. Figen; Kocabey, Yavuz; Dulgeroglu, Turan Cihan; Candemir, Hande
    Objective: The aim of this study was to evaluate the effects of bone marrow-derived mesenchyinal stem cell and bone marrow elements On the healing Of meniscal tears. Methods: This study was performed on twelve, 2-year-old male Tahirova sheep. La each subject, one knee was used for experiment purposes and the other knee was used as a control. After creating a longitudinal full-thickness tear in the red-white zone of the medial meniscus, aspirated autologous bone marrow material was injected into the tear site in the experiment group. The control group received no intervention for secondary healing. Results: In the macroscopic evaluation of meniscus, a bridging reparation tissue and adhesion Were observed between the rims of the tear in the experiment group. There was no statistical difference in collagen fibril formation between the groups (p=0.16). There was significantly more neovascularization in the experiment group than the control group (p=0.003). The cell count was also a significantly higher in the experiment group (p=0.004) and formation Of cartilage plaques was More frequent in the experiment group (p=0.016). There was no evidence suggesting intrinsic repair in the meniscus of control group by light and electron microscopy. Conclusion: An injection Of bone marrow into the meniscus tear site improves healing in a meniscal tear model as demonstrated by both light and electron microscopic findings.
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    Immunocytochemical and ultrastructural organization of the taste thalamus of the tree shrew (Tupaia belangeri)
    (WILEY, 2021-01-01) Maher, Erin E.; Prillaman, McKenzie E.; Keskinoz, Elif N.; Petry, Heywood M.; Erisir, Alev
    Ventroposterior medialis parvocellularis (VPMP) nucleus of the primate thalamus receives direct input from the nucleus of the solitary tract, whereas the homologous thalamic structure in the rodent does not. To reveal whether the synaptic circuitries in these nuclei lend evidence for conservation of design principles in the taste thalamus across species or across sensory thalamus in general, we characterized the ultrastructural and molecular properties of the VPMP in a close relative of primates, the tree shrew (Tupaia belangeri), and compared these to known properties of the taste thalamus in rodent, and the visual thalamus in mammals. Electron microscopy analysis to categorize the synaptic inputs in the VPMP revealed that the largest-size terminals contained many vesicles and formed large synaptic zones with thick postsynaptic density on multiple, medium-caliber dendrite segments. Some formed triads within glomerular arrangements. Smaller-sized terminals contained dark mitochondria
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    Morphological evaluation of the effects of exercise on high-fat-diet-induced liver damage in rats
    (AVES, 2020-01-01) Elmas, Merve Acikel; Atay, Nilsu; Ozakpinar, Ozlem Bingol; Arbak, Serap; Kolgazi, Meltem; Sener, Goksel; Ercan, Feriha
    Background/Aims: This study was aimed to investigate the protective effects of swimming on nonalcoholic fatty liver disease associated with high-fat-diet-induced obesity using microscopic and biochemical parameters. Materials and Methods: Sprague-Dawley male rats were fed either standard chow (STD group