Acıbadem Sağlık Bilimleri Dergisi

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Author: search.filters.author.Karasu, BuğraHas files: Yes

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    Alterations of Neuroretinal and Corneal Thickness in Hashimoto’s Thyroiditis
    (Acıbadem Mehmet Ali Aydınlar Üniversitesi, 2022-01-01) Olcaysü, Osman Okan; Karasu, Buğra; Olcaysü, Elif; Çayır, Atilla; Çelebi, Ali Rıza Cenk
    ABSTRACT Purpose:To compare changes in macula, retinal nerve fiber layer (RNFL) and central corneal thickness (CCT) in patients with Hashimoto’s thyroiditis (HT) with age-matched healthy control group. Materials and Methods: This study was conducted with a prospective, observational, cross-sectional design. The individuals participating in the study were divided into 2 groups: patients with a diagnosis of HT (group 1, n:54 eyes) and age-matched healthy participants (group 2, n:70 eyes). Corneal, retinal and macular thickness measured by optical coherence tomography. Mean outcome measurements were CCT, intra-ocular pressure (IOP), central 1 mm foveal thickness (CFT), subfoveal choroidal thickness (SFCT), total macular volume (TMV), central 1 mm foveal volume (CFV), and RNFL thickness in superior, nasal, inferior and temporal quadrants. Results:The mean IOP was 17.07±2.34μm in group 1 and 14.20±2.76μm in group 2, respectively (p<0.001). Mean CCTs were 539.44±35.27μm and 555.06±40.53μm (p=0.001), CFTs were 227.35±17.52µm and 230.38±23.52µm (p=0.57), SFCT were 210,79±20,13µm and 268,47±24,56µm (p<0.001), TMVs were 7.16±0.35mm3 and 7.02±0.26mm3(p=0.07), CFVs were 0.17±0.01mm3 and 0.19±0.07mm3 (p=0.16) in group 1and group 2, respectively. RNFL thickness values were significantly thinner in the group 1(p<0.05) in all quadrants except for the nasal quadrant (p=0.086). Conclusion:Hypothyroidism secondary to HT may be a determining factor affecting the development of the cornea and retina. Elevated IOP and decrement of RNFL thickness in children with HT increased the risk of developing glaucoma, as well as decreased SFCT may predispose to the development of chorioretinal disorders in the future
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    Evaluation of the Relationships between Obesity and Central Retinal Thickness, Retinal Nerve Fiber Layer, Intraocular Pressure, and Central Corneal Thickness in Children
    (Acıbadem Mehmet Ali Aydınlar Üniversitesi, 2022-01-01) Olcaysü, Osman Okan; Karasu, Buğra; Olcaysü, Elif; Çayır, Atilla; Çelebi, Ali Rıza Cenk
    ABSTRACT Purpose: The purpose of this study was to investigate the effect of childhood obesity on the retinal nerve fiber layer (RNFL), retinal thickness, central corneal thickness and intraocular pressure. Method: Children with obesity (n:24) (Group 1; n:48 eyes) and healthy children (n:23) (Group 2; n:46 eyes) were included in the study. Average RNFL thickness, central 1 mm diameter of foveal thickness (CFT) and subfoveal choroidal thickness (SFCT) were measured using the fourier domain - optical coherence tomography (FD-OCT). Central corneal thickness (CCT) was measured using contact ultrasonic pachymetry and intraocular pressure (IOP) using Goldmann applanation tonometry. Results: The mean IOP in Group 1 was found to be significantly higher (p=0.002) and 16.1 ± 3.1 mmHg in group 1 and 13.6 ± 3.2 mmHg in group 2, respectively. Mean RNFL, CFT and SFCT significantly were lower in group 1 (p < 0.05) than group 2. The average RNFL was detected to 107.9 ± 10.5 µm in group 1 and 112.6±11.8 µm in group 2, respectively (p=0.001). Mean CFT was found to be 231.6±14.4 µm in group 1 and 245.9±19.98 µm in group 2, respectively (p=0.001). The average SFCT was observed to 193.3±15.3 µm in group 1 and 221 ± 25.1 µm in group 2, respectively (p<0.001). Although CCT was relatively higher in group 1, no statistically significant difference was observed among the groups (p=0.08). There was a positive correlation between the presence of obesity and mean IOP measurements (r = 0.847, p = 0.011), and besides a negative correlation was detected between mean RNFL thickness and mean weight of the patients (r = -0.749, p = 0.039). Conclusion: In current study, it should be kept in mind that elevated IOP and decrement of RNFL thickness in children with obesity increased the risk of developing glaucoma, as well as decreased CFT and SFCT may form the basis for the development of macular diseases in future.